Skip Navigation
Genetic and Rare Diseases Information Center (GARD)


Other names people use for this condition
  • Posterior laryngeal cleft (PLC)
  • Type 1A (minor laryngeal cleft)
  • Anterior submucous laryngeal cleft (subtype)
  • Congenital laryngeal clefts (subtype)
  • Cleft, larynx posterior
Printer Friendly printer friendly version
Home > Genetic & Rare Diseases Information Center (GARD) > Laryngeal cleft



Laryngeal cleft
ORDR lists rare diseases for information purposes only and does not guarantee that a condition is rare. Read more
The links on this page may take you to sites outside of the NIH. (See Disclaimer for details.)
A laryngeal cleft is a rare abnormality of the separation between the larynx, or voice box, and the esophagus.[1][2] Normally, when the larynx develops, it is completely separate from the esophagus so swallowed foods go directly into the stomach. When a laryngeal cleft occurs, there is an opening between the larynx and the esophagus so food and liquid can pass through the larynx into the lungs.[1] There are several different types of laryngeal clefts (Types I through IV), classified based on the extent of the clefting.[3][4]


References
  1. Laryngeal Cleft. Children's Hospital Boston. Available at: http://www.childrenshospital.org/az/Site1137/mainpageS1137P0.html. Accessed August 30, 2011.
  2. Pezzettigotta SM, Leboulanger N, Roger G, Denoyelle F, Garabedian EN. Laryngeal Cleft. Otolaryngol Clin North Am. 2008;41:913-933. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18775342. August 30, 2011.
  3. Tewfik TL, Karsan N, Laberge JM. Congenital Malformations of the Esophagus. eMedicine. 2010 Available at: http://emedicine.medscape.com/article/837879-overview. Accessed August 30, 2011.
  4. Rahbar R, Rouillon I, Roger G, Lin A, Nuss RC, Denoyelle F, McGill TJ, Healy GB, Garabedian EN. The Presentation and Management of Laryngeal Cleft. Archives of Ololaryngology-Head & Neck Surgery. 2006;142:1335-1341. Available at: http://archotol.ama-assn.org/cgi/content/full/132/12/1335. August 30, 2011.
click to take you to contact us form

Questions & Answers (Found 1 Question)
A list of questions from the public on rare and/or genetic diseases that have been answered by the Genetic and Rare Disease Information Center. Click on each question to find the answer.
Show All Resources


For more information about Laryngeal cleft click on the boxes below:
More Detailed Information Organizations Services Scientific Conferences Clinical Trials & Research
 General | Selected Full-Text Journal Articles
More Detailed Information (Found 4 resources)
Links where you can find more general information, comprehensive resources, selected full text journal articles, and news updates.

  • General

    • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
    • The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Laryngeal cleft. Click on the link to go to OMIM and review these resources.
    • PubMed is a searchable database of medical literature and lists journal articles that discuss Laryngeal cleft. Click on the link to view a sample search on this topic.
  • Selected Full-Text Journal Articles

 Disease-Specific Organizations | Umbrella Organizations | Social Networking Websites
Organizations (Found 7 resources)
Groups providing a wide range of services, supportive resources, and information.

  • Disease-Specific Organizations

  • Umbrella Organizations

  • Social Networking Websites

    • DNAandU.org is a Web site and blog that collects firsthand stories from people facing issues, making tough decisions, and using genomic (DNA) information in their own healthcare.  Click on the link to learn from their experiences and/or submit your own story.

    • Madisons Foundation
      P.O. Box 241956
      Los Angeles, CA 90024
      Telephone: 310-264-0826
      Fax: 310-264-4766
      E-mail: getinfo@madisonsfoundation.org  
      Web site: http://www.madisonsfoundation.org/  
    • The National Organization of Rare Disorders (NORD) has partnered with Inspire.com to launch an online community for people with rare diseases called The NORD Rare Disease Community. This community connects medical patients, family members, caregivers, and professionals. Click on The NORD Rare Disease Community to learn more.
    • RareShare is an online social hub dedicated to patients, families and healthcare professionals affected by rare medical disorders. Click on RareShare to learn more.
 
Services (Found 2 resources)
Links to Web sites that offer services, such as tools to locate specialists, specialty clinics, genetic services, and genetic testing laboratories.

    • Many individuals want to know about healthcare professionals or researchers who have knowledge of their conditions. When a condition is rare, it can be difficult to find someone who has seen many cases. Although there is no list of experts in rare diseases, GARD's How to Find an Expert fact sheet provides several ways to identify healthcare professionals who have experience with a particular condition. Click on the link to access this resource and learn more.

  • Parent Resources

    • The Parent Technical Assistance Center Network provides a list of the Parent Training and Information Centers in each state. These centers are funded by the United States Department of Education to provide early intervention and special education information and training to parents of children with disabilities from birth to age 26. Click on the link to find the Parent Center in your state.
 Upcoming Conferences | Past Conferences
Scientific Conferences (Found 2 resources)
Resources where you can find information on completed and upcoming scientific conferences and programs.

  • Upcoming Conferences

    • RDCRN 3rd Conference on Clinical Research for Rare Diseases, October 2, 2012
      Location: Hilton Washington DC/Rockville Hotel & Executive Meeting Center, Rockville, MD
      Description: Clinical research in rare diseases presents a number of challenges and unique issues that are not usually considered in the training of clinical investigators through existing training programs. Goals of the conference include: Direct instruction of trainees and new investigators in rare disease research methodology; Development of a reusable curriculum/syllabus on rare disease research methodology; Stimulation of ideas regarding the unique issues facing investigators engaged in the study of rare diseases
  • Past Conferences

 
Clinical Trials & Research (Found 2 resources)
Resources where you may find research studies and clinical trials.

    • NIH Clinical Trials and You is a website developed by the National Institutes of Health (NIH) to help people learn more about clinical trials, why they matter, and how to participate.
  • Patient Registry

    • ResearchMatch is a free national research registry designed to bring together patients, healthy volunteers and researchers. Anyone from the United States can register with ResearchMatch, and a parent, legal guardian, or caretaker may register on behalf of a volunteer. Researchers from participating institutions use the ResearchMatch database to search for patients or healthy volunteers who meet the study criteria. Many studies are looking for healthy people of all ages, while some are looking for people with specific illnesses. ResearchMatch was developed by major academic institutions across the country and is funded by the National Center for Research Resources (NCRR), a center of the National Institutes of Health (NIH), the primary Federal agency for conducting and supporting medical research. Click on the link to learn more about ResearchMatch.

Department of Health & Human Services National Institutes of Health USA.gov - government made easy