The lifetime risk of individuals with familial adenomatous polyposis (FAP) to develop thyroid carcinoma has been reported to range from 2-12%. Most patients are females under the age of 30. About 95% of these cancers are papillary thyroid carcinomas.[1][2]
The following resources discuss the association between papillary thyroid cancer and FAP / Gardner syndrome.
Online Mendelian Inheritance in Man (OMIM), an electronic catalog of human genes and genetic disorders, lists papillary thyroid carcinoma (cancer) under neoplasias associated with FAP / Gardner syndrom. Visit the following link to view the OMIM page for this topic:
http://omim.org/clinicalSynopsis/175100
The National Cancer Institute (NCI) discusses extracolonic tumors which are associated with FAP / Gardner syndrome at the following link. Papillary thyroid cancer is among the tumors described.
http://www.cancer.gov/cancertopics/pdq/genetics/colorectal/HealthProfessional/page4#Section_251
You can find relevant articles on papillary thyroid cancer in FAP / Gardner syndrome through PubMed, a searchable database of biomedical journal articles. Although not all of the articles are available for free online, most articles listed in PubMed have a summary available. To obtain the full article, contact a medical/university library or your local library for interlibrary loan. You can also order articles online through the publisher’s Web site. Using 'papillary thyroid cancer AND FAP' as your search term should help you locate articles. Use the advanced search feature to narrow your search results. Click here to view a search.
http://www.ncbi.nlm.nih.gov/PubMed
The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link http://nnlm.gov/members/. You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.
Several articles which discuss the association are linked below.
Jarrar AM, Milas M, Mitchell J, Laguardia L, O'Malley M, Berber E, Siperstein A, Burke C, Church JM. Screening for thyroid cancer in patients with familial adenomatous polyposis. Ann Surg. 2011 Mar;253(3):515-21.
Martayan A, Sanchez-Mete L, Baldelli R, Falvo E, Barnabei A, Conti L, Giacomini P, Appetecchia M, Stigliano V. Gene variants associated to malignant thyroid disease in familial adenomatous polyposis: a novel APC germline mutation. J Endocrinol Invest. 2010 Oct;33(9):603-6.
Harb WJ, Sturgis EM. Differentiated thyroid cancer associated with intestinal polyposis syndromes: a review. Head Neck. 2009 Nov;31(11):1511-9.
Groen EJ, Roos A, Muntinghe FL, Enting RH, de Vries J, Kleibeuker JH, Witjes MJ, Links TP, Van Beek AP: Extra-intestinal manifestations of familial adenomatous polyposis. Ann Surg Oncol 2008, 15:2439-2450. (PMID: 18612695)
Cetta F, Montalto G, Gori M, Curia MC, Cama A, Olschwang S. Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: results from a European cooperative study. J Clin Endocrinol Metab. 2000 Jan;85(1):286-92.
Truta B, Allen BA, Conrad PG, Kim YS, Berk T, Gallinger S, Bapat B, Terdiman JP, Sleisenger MH. Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma. Fam Cancer. 2003;2(2):95-9.
Herraiz M, Barbesino G, Faquin W, Chan-Smutko G, Patel D, Shannon KM, Daniels GH, Chung DC. Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. Clin Gastroenterol Hepatol. 2007 Mar;5(3):367-73. Epub 2007 Jan 26.