Skip Navigation
Genetic and Rare Diseases Information Center (GARD)


Other names people use for this condition
  • KSS
  • Ophthalmoplegia, pigmentary degeneration of retina, and cardiomyopathy
  • Oculocraniosomatic syndrome
  • Ophthalmoplegia plus syndrome
  • Mitochondrial cytopathy
  • Ophthalmoplegia, progressive external, with ragged red fibers
  • Chronic progressive external ophthalmoplegia with myopathy
  • CPEO with myopathy
  • CPEO with ragged red fibers



Kearns Sayre syndrome
ORDR lists rare diseases for information purposes only and does not guarantee that a condition is rare. Read more
The links on this page may take you to sites outside of the NIH. (See Disclaimer for details.)


Kearns-Sayre syndrome (KSS) is a neuromuscular disorder defined by the triad of onset before age 20 years, pigmentary retinopathy (a "salt-and-pepper" pigmentation in the retina that can affect vision, but often leaves it intact), and progressive external ophthalmoplegia (PEO).[1][2][3] In addition, affected individuals have at least one of the following: cardiac conduction block, cerebrospinal fluid protein concentration greater than 100 mg/dL, or cerebellar ataxia. Kearns-Sayre syndrome is a mitochondrial DNA (mtDNA) deletion syndrome.[1] It results from abnormalities in the DNA of mitochondria - small rod-like structures found in every cell of the body that produce the energy that drives cellular functions. This and other mitochondrial diseases correlate with specific DNA mutations that cause problems with many of the organs and tissues in the body, resulting in multisystem effects. Treatment for this slowly progressive disorder is generally symptomatic and supportive.[2]






References
  1. DiMauro S, Hirano M. Mitochondrial DNA Deletion Syndromes. GeneReviews. April 19, 2007 Available at: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=kss. Accessed January 13, 2009.
  2. NINDS Kearns-Sayre Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). February 13, 2007 Available at: http://www.ninds.nih.gov/disorders/kearns_sayre/kearns_sayre.htm. Accessed January 13, 2009.
  3. Facts about Mitochondrial Myopathies. Muscular Dystrophy Association (MDA). September 2008 Available at: http://www.mda.org/publications/mitochondrial_myopathies.html. Accessed January 13, 2009.
click to take you to contact us form

Questions & Answers (Found 1 Question)
A list of questions from the public on rare and/or genetic diseases that have been answered by the Genetic and Rare Disease Information Center. Click on each question to find the answer.


For more information about Kearns Sayre syndrome click on the boxes below:
More Detailed Information Organizations Services Scientific Conferences Clinical Trials & Research