Genetic and Rare Diseases Information Center (GARD)


Other names people use for this condition
  • Felty syndrome
  • Rheumatoid arthritis, splenomegaly and neutropenia
  • Familial Felty's syndrome



Felty's syndrome
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Felty syndrome is defined by the triad of rheumatoid arthritis (RA), an enlarged spleen (splenomegaly) and a low white blood cell count (neutropenia).[1][2][3][4] It affects approximately 1% of patients with RA, most often a few years after the onset of RA.[2] The exact cause of Felty syndrome is unknown. It is believed to be an autoimmune disorder that may be genetically transmitted as an autosomal dominant trait.[1]

References
  1. Felty Syndrome. National Organization for Rare Disorders (NORD). 2006 Available at: http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Felty%20Syndrome. Accessed May 14, 2009.
  2. Felty syndrome. Orphanet. 2003 Available at: http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=47612. Accessed May 14, 2009.
  3. Keating RM. Felty Syndrome. eMedicine. 2008 Available at: http://emedicine.medscape.com/article/329734-overview. Accessed May 14, 2009.
  4. Robert S Pinals. Kelly's Textbook of Rheumatology, 8th edition. In: . Chapter 68 - Felty's Syndrome. Philadelphia, PA:WB Saunders Company; 2008:

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