Crohn's disease

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* This condition is not a rare disease. It is a condition about which the GARD Information Center has received a question.

Crohn's disease *
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Crohn disease is an inflammatory bowel disease (IBD), the general name for diseases that cause inflammation in the intestines. Common symptoms are pain in the abdomen and diarrhea. Bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. Other problems can include intestinal blockage and malnutrition. It can occur in people of all age groups but is most often diagnosed in young adults. Crohn's disease seems to run in some families.^[1]

References

Crohn's disease. National Digestive Diseases Information Clearinghouse (NIDDC). February 2006 Available at: http://digestive.niddk.nih.gov/ddiseases/pubs/crohns/index.htm. Accessed December 27, 2007.

Questions & Answers (Found 1 Question)

A list of questions from the public on rare and/or genetic diseases that have been answered by the Genetic and Rare Disease Information Center. Click on each question to find the answer.

My father has Crohn's disease for which he has had many surgeries in his lifetime. His brother (my uncle) also had this disease as a young adult. Can you tell me what percent chance I would have of having this disease as well? My fathers other young adult children do not have it as of yet. (Click here for answer)

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For more information about Crohn's disease click on the boxes below:

More Detailed Information	NLM Gateway	Medical Products	Services	Support Groups	Clinical Trials & Research


More Detailed Information (Found 7 resources) Links where you can find more general information, comprehensive resources, selected full text journal articles, and news updates General UC and Crohn's, a Web site for kids and teens with ulcerative colitis or Crohn's disease sponsored by the Crohn's & Colitis Foundation of America (CCFA). eMedicine provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free Genetics Home Reference (GHR) contains a condition summary on Crohn's disease. Click on the link to go to GHR and review this summary. MedlinePlus, a Web site designed by the National Library of Medicine Web site to help you research your health questions, provides more information about this topic. Click on the link to view this information. The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information. The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Crohn's disease. Click on the link to go to OMIM and review these resources. PubMed is a searchable database of medical literature and lists journal articles that discuss Crohn's disease. Click on the link to view a sample search on this topic.

More Detailed Information (Found 7 resources)
Links where you can find more general information, comprehensive resources, selected full text journal articles, and news updates

General
- UC and Crohn's, a Web site for kids and teens with ulcerative colitis or Crohn's disease sponsored by the Crohn's & Colitis Foundation of America (CCFA).
- eMedicine provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free
- Genetics Home Reference (GHR) contains a condition summary on Crohn's disease. Click on the link to go to GHR and review this summary.
- MedlinePlus, a Web site designed by the National Library of Medicine Web site to help you research your health questions, provides more information about this topic. Click on the link to view this information.
- The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Crohn's disease. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Crohn's disease. Click on the link to view a sample search on this topic.


NLM Gateway (Found 1 resource) A tool to search across multiple resources offered on the National Library of Medicine's Website NLM Gateway allows users to search many resources offered on the National Library of Medicine's Web site at once to quickly find more information about this condition. Some of the resources may be a duplicate of the resources listed on this page. To search NLM Gateway, click on the link; the condition name will already be in the search box, so you can just click the “Search” button.

NLM Gateway (Found 1 resource)
A tool to search across multiple resources offered on the National Library of Medicine's Website

- NLM Gateway allows users to search many resources offered on the National Library of Medicine's Web site at once to quickly find more information about this condition. Some of the resources may be a duplicate of the resources listed on this page. To search NLM Gateway, click on the link; the condition name will already be in the search box, so you can just click the “Search” button.

Medical Products (Found 1 resource)

U.S. Food and Drug Administration

The Office of Orphan Products Development (OOPD)

The medications listed in the table below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search all FDA approved drugs, visit Drugs@FDA You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.

Generic Name	Trade Name (Manufacturer Name)	Indication	Resources
Infliximab	Remicade® (Centocor Ortho Biotech Inc.)	For reducing signs and symptoms and inducing and maintaining clinical remission in pediatric patients with moderately to severely active Crohn's disease who have had an inadequate response to conventional therapy	Daily Med


Services (Found 1 resource) Links to Web sites that offer services, such as tools to locate specialists, specialty clinics, genetic services, and genetic testing laboratories Ask-an-Expert The Crohn's and Colitis Foundation of America's Information Resource Center (IRC) provides accurate, current, disease-related information to the public, health care professionals, patients and their families. Contact the IRC to understand diagnosis, treatment, and living with Crohn's disease and ulcerative colitis. IRC information specialists are master's level health professionals. They are available Monday through Friday, 9 a.m. to 5 p.m. Eastern Time. Call toll-free 1-888.MY.GUT.PAIN or use the IRC contact form.

Services (Found 1 resource)
Links to Web sites that offer services, such as tools to locate specialists, specialty clinics, genetic services, and genetic testing laboratories

Ask-an-Expert
- The Crohn's and Colitis Foundation of America's Information Resource Center (IRC) provides accurate, current, disease-related information to the public, health care professionals, patients and their families. Contact the IRC to understand diagnosis, treatment, and living with Crohn's disease and ulcerative colitis. IRC information specialists are master's level health professionals. They are available Monday through Friday, 9 a.m. to 5 p.m. Eastern Time. Call toll-free 1-888.MY.GUT.PAIN or use the IRC contact form.

Umbrella Organizations \| Disease-Specific Organizations \| Live Chat/E-mail Lists \| Parent Matching Organizations
Support Groups (Found 6 resources) Groups providing a wide range of services, supportive resources, and information Umbrella Organizations Genetic Alliance 4301 Connecticut Avenue NW Suite 404 Washington, DC 20008-2369 Telephone: 202-966-5557 Fax: 202-966-8553 E-mail: info@geneticalliance.org Web site: http://www.geneticalliance.org National Organization for Rare Disorders (NORD) 55 Kenosia Avenue PO Box 1968 Danbury, CT 06813-1968 Toll-free: 1-800-999-6673 (voicemail only) Telephone: 203-744-0100 TTY: 203-797-9590 Fax: 203-798-2291 E-mail: orphan@rarediseases.org Web site: http://www.rarediseases.org/ Disease-Specific Organizations Crohn's & Colitis Foundation of America 386 Park Avenue South, 17th Floor New York, NY 10016–8804 Toll-free: 1–800–932–2423 E-mail: info@ccfa.org Web site: http://www.ccfa.org Live Chat/E-mail Lists The National Organization of Rare Disorders (NORD) has partnered with Inspire.com to launch an online community for people with rare diseases called The NORD Rare Disease Community. This community connects medical patients, family members, caregivers, and professionals. Click on The NORD Rare Disease Community to learn more. RareShare is an online social hub dedicated to patients, families and healthcare professionals affected by rare medical disorders. Click on RareShare to learn more. Parent Matching Organizations Madisons Foundation P.O. Box 241956 Los Angeles, CA 90024 Telephone: 310-264-0826 Fax: 310-264-4766 E-mail: getinfo@madisonsfoundation.org Web site: http://www.madisonsfoundation.org/

Umbrella Organizations | Disease-Specific Organizations | Live Chat/E-mail Lists | Parent Matching Organizations

Support Groups (Found 6 resources)
Groups providing a wide range of services, supportive resources, and information

Umbrella Organizations
- Genetic Alliance
  4301 Connecticut Avenue NW
  Suite 404
  Washington, DC 20008-2369
  Telephone: 202-966-5557
  Fax: 202-966-8553
  E-mail: info@geneticalliance.org
  Web site: http://www.geneticalliance.org
- National Organization for Rare Disorders (NORD)
  55 Kenosia Avenue
  PO Box 1968
  Danbury, CT 06813-1968
  Toll-free: 1-800-999-6673 (voicemail only)
  Telephone: 203-744-0100
  TTY: 203-797-9590
  Fax: 203-798-2291
  E-mail: orphan@rarediseases.org
  Web site: http://www.rarediseases.org/
Disease-Specific Organizations
- Crohn's & Colitis Foundation of America
  386 Park Avenue South, 17th Floor
  New York, NY 10016–8804
  Toll-free: 1–800–932–2423
  E-mail: info@ccfa.org
  Web site: http://www.ccfa.org
Live Chat/E-mail Lists
- The National Organization of Rare Disorders (NORD) has partnered with Inspire.com to launch an online community for people with rare diseases called The NORD Rare Disease Community. This community connects medical patients, family members, caregivers, and professionals. Click on The NORD Rare Disease Community to learn more.
- RareShare is an online social hub dedicated to patients, families and healthcare professionals affected by rare medical disorders. Click on RareShare to learn more.
Parent Matching Organizations
- Madisons Foundation
  P.O. Box 241956
  Los Angeles, CA 90024
  Telephone: 310-264-0826
  Fax: 310-264-4766
  E-mail: getinfo@madisonsfoundation.org
  Web site: http://www.madisonsfoundation.org/


Clinical Trials & Research (Found 2 resources) Resources where you may find research studies and clinical trials ClinicalTrials.gov lists trials that are studying or have studied Crohn's disease. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies. The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.

Clinical Trials & Research (Found 2 resources)
Resources where you may find research studies and clinical trials

- ClinicalTrials.gov lists trials that are studying or have studied Crohn's disease. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
- The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.

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