Start of Main Content
National Cancer Institute (NCI)

Barrett's Esophagus and Esophageal Adenocarcinoma (BEEA) Workshop
May 9 – 10, 2005 Bethesda, MD


Agenda Speakers Workshop Summary

Agenda

Monday, May 9
 
8:30 a.m. Welcome
Wong-Ho Chow, Olof Nyrén, and Tom Vaughan
8:45 a.m. Welcome
Joe Fraumeni, Jr.
8:50 a.m.

Introduction
Participants
9:10 a.m. Interlymph consortium experience
Patricia Hartge
9:30 a.m. NIDDK: Opportunities for support
Frank Hamilton
9:40 a.m. NCI: EGRP consortia activities
Daniela Seminara
10:00 a.m. Summary of studies
Wong-Ho Chow
10:10 a.m. High-throughput molecular assays and NCI Core Genotyping Facility
Stephen Chanock
11:00 a.m. Study-specific issues
Principal Investigators

  • Australia EA and BE studies
    David Whiteman
  • Canada EA study
    Alan Casson
  • Ireland EA and BE studies
    Liam Murray
  • Kaiser EA study
    Douglas Corley
  • Sweden EA study
    Olof Nyrén
  • UNC BE study
    Nicholas Shaheen
  • USC EA study
    Anna Wu and Leslie Bernstein
  • U.S. Black/White EA study
    Linda Brown
  • Seattle BE study
    Tom Vaughan
  • U.S. multicenter EA study
    Marilie Gammon, Harvey Risch, Tom Vaughan, and Wong-Ho Chow
1:30 p.m.

Discussion with invited experts: Promising areas for collaboration
Stephen Chanock, Emad El-Omar, Ernie Hawk, Susan Mayne, Kenneth McColl, Brian Reid, and Christopher Wild
3:30 p.m. Group discussion on possible areas of collaboration
Participants
5:00 p.m. Plan for Day 2 discussion topics
Participants
 
Tuesday, May 10
 
8:30 a.m.

Group discussions
Participants
11:00 a.m.

Group discussions
Participants
1:30 p.m. Group discussions
Participants
2:30 p.m. Summary and closing
Wong-Ho Chow, Olof Nyrén, and Tom Vaughan

Back to top of page

Speakers

Leslie Bernstein, Ph.D.
Professor, Preventive Medicine
Keck School of Medicine
University of Southern California
Norris Cancer Center
1441 Eastlake Avenue, Room 4449
Los Angeles, CA 90033

Linda Morris Brown, M.P.H., Dr.P.H.
Assistant Chief
Biostatistics Branch
Division of Cancer Epidemiology
and Genetics
National Cancer Institute
Executive Plaza South, Room 8026
6120 Executive Boulevard
Bethesda, MD 20892-7244

Alan Casson, F.R.C.S.C.
Professor of Surgery
QE II Health Sciences Centre
Dalhousie University
1278 Tower Road
Victoria Building 7S-013
Halifax, Nova Scotia B3H 2Y9
Canada

Stephen Chanock, M.D.
Senior Investigator
Pediatric Oncology Branch, CCR
National Cancer Institute
Advanced Technology Center
8717 Grovemont Circle
Gaithersburg, MD 20877

Wong-Ho Chow, Ph.D.
Senior Investigator
Occupational Epidemiology Branch
Division of Cancer Epidemiology
and Genetics
National Cancer Institute
Executive Plaza South, Room 8100
6120 Executive Boulevard
Bethesda, MD 20892-7240

Douglas Corley, M.D., Ph.D.
Research Scientist II
Division of Research
Kaiser Permanente
2000 Broadway Street
Oakland, CA 94612

Emad El-Omar, M.D.
Professor of Gastroenterology
Department of Medicine and Therapeutics
Institute of Medical Sciences
Aberdeen University
Foresterhill, Aberdeen AB25 2ZD
United Kingdom

Joseph Fraumeni, Jr., M.D.
Director
Division of Cancer Epidemiology
and Genetics
National Cancer Institute
Executive Plaza South, Room 8070
6120 Executive Boulevard
Bethesda, MD 20892-7242

Marilie Gammon, Ph.D.
Professor and Deputy Director
Department of Epidemiology
UNC Center for Environmental Health
and Susceptibility
University of North Carolina
2102C McGavran-Greenberg Hall
CB#7435
Chapel Hill, NC 27599-7435

Frank Hamilton, M.D., M.P.H.
Chief, Digestive Disease Branch
Division of Digestive Diseases and
Nutrition
National Institute of Diabetes and Digestive
and Kidney Diseases
2 Democracy Plaza, Room 669
6707 Democracy Boulevard
Bethesda, MD 20892-5450

Patricia Hartge, Sc.D.
Epidemiology and Biostatistics
Program
Division of Cancer Epidemiology
and Genetics
National Cancer Institute
Executive Plaza South, Room 8090
6120 Executive Boulevard
Rockville, MD 20852

Ernest Hawk, M.D., M.P.H.
Director
Office of Centers, Training, and Resources
National Cancer Institute
6116 Executive Boulevard, Suite 700
Bethesda, MD 20892-8345

Susan Mayne, Ph.D.
Department of Epidemiology and
Public Health
Yale University School of Medicine
60 College Street
P.O. Box 208034
New Haven, CT 06520-8034

Kenneth McColl, M.D.
Head, Division of Gastroenterology
Department of Medicine and Therapeutics
University of Glasgow
Western Infirmary Glasgow
44 Church Street
Glasgow, Scotland G11 6NT
United Kingdom

Liam Murray, M.D., M.F.P.H.M.
Senior Lecturer in Epidemiology and
Public Health
Centre for Clinical and Population Sciences
Queen's University Belfast
Mulhouse Building
Grosvenor Road
Belfast BT12 6BJ
United Kingdom

Olof Nyrén, M.D, Ph.D.
Professor of Clinical Epidemiology
Department of Medical Epidemiology
and Biostatistics
Karolinska Institutet
Box 281
SE-171 77 Stockholm
Sweden

Brian Reid, M.D., Ph.D.
Member
Division of Human Biology and Public
Health Sciences
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North, C1-157
P.O. Box 19024
Seattle, WA 98109

Harvey Risch, M.D., Ph.D.
Department of Epidemiology and
Public Health
Yale University School of Medicine
60 College Street
P.O. Box 208034
New Haven, CT 06520-8034

Daniela Seminara, Ph.D., M.P.H.
Clinical and Genetic Epidemiology
Research Branch
Division of Cancer Epidemiology
and Genetics
National Cancer Institute
Executive Plaza North, Room 5142
6130 Executive Boulevard
Rockville, MD 20852

Nicholas Shaheen, M.D., M.P.H.
Associate Professor of Medicine and
Epidemiology
Director, Center for Esophageal Diseases
and Swallowing
University of North Carolina School
of Medicine
Bioinformatics Building, Room 4102
Carolina Campus, CB#7080
Chapel Hill, NC 27599-7080

Thomas Vaughan, M.D., M.P.H.
Professor and Program Head, Epidemiology
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North (M4-B874)
P.O. Box 19024
Seattle, WA 98109

David Whiteman, M.B.B.S., Ph.D.
Senior Research Fellow
Queensland Institute of Medical Research
300 Herston Road
Herston, Brisbane
Australia

Chris Wild, Ph.D.
Professor
Molecular Epidemiology Unit
LIGHT Laboratories
University of Leeds
Clarendon Way
Leeds LS2 9JT
United Kingdom

Anna Wu, Ph.D.
Professor
Keck School of Medicine
University of Southern California
Norris Comprehensive Cancer Center
Los Angeles, CA 90089-9175


Back to top of page

Summary

Incidence rates for esophageal adenocarcinoma (EA) have risen steeply in the United States and other Western countries during the past 30 years. Among white men in the United States, the increases have outpaced any other cancers. Rates also have increased substantially among blacks of both sexes and white women.

Investigators have been able to identify a few moderately strong risk factors for esophageal adenocarcinoma and its precursor, Barrett’s esophagus, including tobacco use, obesity, and gastroesophageal reflux. However, progress in research on this cancer has been limited by small study populations. “Because this cancer is relatively uncommon, many of the studies, at least the first-generation investigations, involved small numbers of subjects and an even smaller subset of subjects who provided biospecimens,” said Wong-Ho Chow, Ph.D., Occupational and Environmental Epidemiology Branch. One approach for surmounting the problem of small numbers is the formation of a consortium—a voluntary network of scientists who have agreed to cooperative research efforts to enable the sharing of ideas, data, tools, and specimens across two or more population-based studies.

Building a foundation for the new Barrett’s Esophagus and Adenocarcinoma Consortium (BEACON) was the topic of a workshop held on May 9 and 10, 2005, with support provided by the NIH Office of Rare Diseases. Planned by Dr. Chow, Dr. Olof Nyrén of the Karolinska Institutet in Stockholm, and Dr. Thomas Vaughan of the Fred Hutchinson Cancer Research Center in Seattle, the workshop was attended by more than three dozen scientists from the United States, Europe, and Australia. The workshop represented the start of collaborative efforts among researchers dedicated to the study of Barrett’s esophagus and esophageal adenocarcinoma.

During the workshop, principal investigators from 14 separately funded case-control studies outlined the types of data and biospecimens available, described the status of ongoing and completed research, and identified possible avenues for collaborative work. Several laboratory and clinical investigators gave presentations on state-of-science research that may be applied to these tumors. Dr. Daniela Seminara and Dr. Ernest Hawk of NCI, as well as Dr. Frank Hamilton and Dr. Jay Everhart of the National Institute of Diabetes and Digestive and Kidney Diseases, provided information about possible sources of support for the consortium’s activities. Some participants spoke about their experiences with other consortia. Stephen Chanock, M.D., Advanced Technology Center, described the resources available through the NCI Core Genotyping Facility for high-throughput genotyping to support BEACON’s efforts.

The second day of the workshop was devoted to developing an organizational framework for BEACON, which will consist of four working groups and a steering committee. Plans were made to develop short, intermediate, and long-term projects. Consortium members agreed to communicate regularly by telephone and other means before meeting again in the spring of 2006.

Back to Scientific Conferences Home


Last Reviewed: July 5, 2005
Back to Top
Back to Top