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National Institute of Child Health and Human Development (NICHD)

Fetal Therapy Symposium
April 17 – 18, 1997 • Bethesda, Maryland


Agenda Participants Workshop Summary

Agenda

Thursday, April 17
 
8:30 a.m. Welcome
Felix de la Cruz, M.D.
National Institute of Child Health and Human Development (NICHD)

Stephen C. Groft, Pharm. D.
Director, Office of Rare Diseases, OD

Duane Alexander, M.D.
Director, NICHD

Moderator
Mark Evans, M.D.
Hutzel Hospital

8:45 a.m. Overview
Mark Evans, M.D.
9:00 a.m. The Ultrasonic Detection of Structural Abnormalities
Mary D’Alton, M.D., Tufts University School of Medicine
9:40 a.m. First Trimester Embryoscopy I
Professor Yves Dumez, Grolupe Hospitalier Couchin
10:55 a.m. First Trimester Embryoscopy II
E. Albert Reece, M.D.
Temple University School of Medicine
11:15 a.m. Evaluation and Therapies of Uropathies
Mark Paul Johnson, M.D.
Hutzel Hospital
12:00 noon Discussion
Moderator
Mary D’Alton, M.D.
1:15 p.m. 2nd Trimester Fetoscopic Intervention
Ruben Quintero, M.D.
Florida Perinatal Associates
2:10 p.m. Surgically Correctable Fetal Diseases
Michael Harrison, M.D.
University of California, San Francisco
3:00 p.m. Ethical Dimensions of the Fetus as a Patient
Frank Chervenak, M.D.
Cornell University Medical Center
3:45 p.m. Management of Fetal Lung Lesions
Scott Adzick, M.D.
Children’s Hospital of Philadelphia
4:15 p.m. Open Surgery for Fetal Sacrococcygeal Teratomas
Alan Flake, M.D.
Children’s Hospital of Philadelphia
 
Friday, April 18
 
8:30 a.m. Moderator
Mark Evans, M.D.

The Implications of Prenatal Diagnosis of Cardiac Disease in the Human Fetus
Charles Kleinman, M.D.
Yale University School of Medicine

9:15 a.m. Maternal PKU
Lawrence Platt, M.D.
Cedars-Sinai Medical Center
10:00 a.m. Metabolic Therapy
Mark Evans, M.D.
10:45 a.m. Prenatal Therapy for Inborn Errors of Sterol and Protein Metabolism
Mira Irons, M.D.
New England Medical Center
11:15 a.m. Ethics in Fetal Therapy: A Historical Perspective
John Fletcher, Ph.D.
University of Virginia
1:00 p.m. In utero Hematopoietic Stem Cell Transplantation
Alan Flake, M.D.
2:00 p.m. In utero Stem Cell Therapy
Karin Blakemore, M.D.
Johns Hopkins Hospital

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Participants

Scott Adzick, M.D.
Department of Surgery
Children's Hospital of Philadelphia
34th and Civic Center Boulevard
Philadelphia, Pennsylvania 19104

Karin Blakemore, M.D.
Johns Hopkins Hospital
Department of OB/GYN
Houck 228
600 N. Wolfe Street
Baltimore, Maryland 21287

Frank Chervenak, M.D.
Department of OB/GYN
Cornell University Medical Center
525 East 68th Street
New York, New York 10020

Mary D' Alton, M.D.
Professor, Department of OB/GYN
Tufts University School of Medicine
750 Washington Street
NEMCH #360
Boston, Massachusetts 02111

Professor Yves Dumez
Grolupe Hospitalier Cochin
Clinique Universitaire Port-Royal
123, Boulevard Port-Royal
75014 Paris
FRANCE

Mark Evans, M.D.
Hutzel Hospital
Department of OB/GYN
Division of Reproductive Genetics
4707 St. Antoine
Detroit, Michigan 48201

Alan Flake, M.D.
Department of Surgery
Children's Hospital of Philadelphia
34th and Civic Center Boulevard
Philadelphia, Pennsylvania 19104

John C. Fletcher, Ph.D.
Center for Biomedical Ethics
Box 348 HSC
University of Virginia
Charlottesville, Virginia 22908

Michael Harrison, M.D.
Fetal Treatment Center
University of California, San Francisco
513 Parnassus Avenue, Room 1601, HSW
Box 0570
San Francisco, California 94143-0570

Mira Irons, M.D.
Clinical Genetics
New England Medical Center
Box 340
751 Washington Street
Boston, Massachusetts 02111

Mark Paul Johnson, M.D.
Hutzel Hospital
Department of OB/GYN
Division of Reproductive Genetics
4707 St. Antoine
Detroit, Michigan 48201

Charles Kleinman, M.D.
Pediatric Cardiology
Yale University School of Medicine
333 Cedar Street
New Haven, Connecticut 06520

Lawrence D. Platt, M.D.
Cedars-Sinai Medical Center
Department of OB/GYN
8615 West Third Street
Suite 160
Los Angeles, California 90048

Ruben A. Quintero, M.D.
Florida Perinatal Associates
13601 Bruce B. Downs Boulevard
Suite 160
Tampa, Florida 33613

E. Albert Reece, M.D.
The Abraham Roth Professor and Chair
Department of OB/GYN, and Reproductive
Sciences
Temple University School of Medicine
3401 North Broad Street, 7-OPD
Philadelphia, Pennsylvania 19140

NIH Participants

Duane Alexander, M.D.
Director
National Institute of Child Health and Human Development
Building 31, Room 2A03
31 Center Drive
9000 Rockville Pike
Bethesda, Maryland 20892

Felix de la Cruz, M.D., M.P.H.
Chief
Mental Retardation and Developmental
Disabilities Branch, CRMC, NICHD
Building 6100, Room 4B09
6100 Executive Boulevard, MSC 7510
Bethesda, Maryland 20892-7510

Stephen Groft, Pharm.D.
Director
Office of Rare Diseases
National Institutes of Health
7550 Wisconsin Avenue
Federal Building, Room 618
Bethesda, Maryland 20892-9120

Sumner J. Yaffe, M.D.
Director
Center for Research for Mothers and Children
Building 6100, Room 4B05
6100 Executive Boulevard, MSC 7510
Bethesda, Maryland 20892-7510


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Summary

A symposium on FetaI Therapy was organized and cosponsored by the Mental Retardation and Developmental Disabilities Branch of the National Institute of Child Health and Human Development, and was held at the NIH on April 17-18, 1997 and the NIH Office of Rare Diseases. This well attended conference brought together a multidisciplinary group of investigators representing obstetrics, perinatology, pediatrics, surgery, genetics, ethics, and other specialty groups. Presentations included various techniques for prenatal diagnosis, such as ultrasonography and embryoscopy, as well as surgical intervention, prenatal therapy for inborn errors of metabolism, in utero stem cell therapy, and ethics in fetal therapy.

The proceedings of the conference are currently being edited and will be published as a book by the Parthenon Publishing Company. Although there are no immediate plans to publish a program announcement or an RFA (request for grant applications), NICHD staff has made informal solicitation for research grants on prenatal diagnosis and fetal therapy. Moreover, a follow-up conference is being planned by NICHD with programmatic co-sponsorship by the Society of Perinatal Obstetricians and the American Institute of Ultrasound in Medicine.

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Last Reviewed: February 4, 2004
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