National Library of Medicine (NLM)
Overview of NLM Rare Diseases in Children Research Activities, FY 2000FY 2005
NLM provides information resources useful to rare disease research and to those seeking information about
conditions affecting themselves or their families.
In addition to providing informational support for all rare diseases (including those in children) through the
NLM collection, PubMed, MEDLINEplus, ClinicalTrials.gov, and numerous other products and services, several ongoing NLM activities are specifically related to rare diseases in children, including:
National Center for Biotechnology Information (NCBI)
The NCBI, a division of NLM, serves as a national public resource for molecular biology information. In
this capacity, NCBI establishes and maintains various genomic databases and develops software tools for
mining and analyzing this data, all of which are freely disseminated to the biomedical community to facilitate a better understanding of the processes affecting human health and disease.
Online Mendelian Inheritance in Man (OMIM)
The OMIM database is a continuously updated catalog of inherited human disorders and their causal
mutations, authored and edited by Dr. Victor A. McKusick and colleagues and developed for the World
Wide Web by NLM.
Malaria is estimated to cause more than one million deaths each year worldwide. The vast majority of
deaths occur among young children in Africa. NLM chairs the Communications Working Group of the
Multilateral Initiative on Malaria, which began in 1997. The objective is to support African scientists and
the ability of malaria researchers to connect with each other and sources of information through full access
to the Internet and the resources of the World Wide Web, as well as create new collaborations and partnerships (see http://www.mimcom.net).
Additionally, NLM, in collaboration with NIAID, supports the efforts to sequence and analyze the
complete genome of
thereby providing researchers with access to information relative to all
of the genes found in this parasite.