Corneal dystrophy Fuchs endothelial 1
Other Names for this Disease
- Corneal dystrophy Fuchs endothelial early-onset
- Early-onset Fuchs endothelial corneal dystrophy
- Fuchs endothelial corneal dystrophy 1
- Fuchs' endothelial dystrophy type 1
Your QuestionI was diagnosed with Fuch's dystrophy many years ago, but I think I may actually have lattice dystrophy. How can I find out for sure?
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Questions on this page
Lattice dystrophies are characterized by the build up of protein fibers (i.e., amyloid) in the stroma. Symptoms may include corneal erosions, decreased vision, photosensitivity, and eye pain. Most cases of lattice dystrophy are caused by mutations in the TGFBI gene.
Lattice dystrophy type 1 is the most common type of lattice dystrophy. It is characterized by fine rod-like glassy opacities (i.e., lattice lines) near the front of the stroma. The opacities often appear in the first or second decade of life and worsen over time. Recurrent corneal erosions are common, which may result in decreased vision, photosensitivity, and eye pain. It is inherited in an autosomal dominant pattern.
GeneTests.org lists a laboratory that is offering clinical genetic testing for this condition. In general, clinical genetic tests may be ordered to help diagnose a person or family, to confirm a diagnosis, and/or to aid in decisions regarding medical care or reproductive issues. We recommend that you talk to your health care provider or a genetic professional to learn more about your testing options, including the costs and benefits of testing.
In addition, the National Eye Institue provides tips for finding an eye specialist at the following link. The NEI was created to conduct research, distribute health information, and support other programs that protect and prolong the vision of Americans.
While not an exaustive list of specialty eye centers, you can find a list of the American Association of Eye and Ear Hospitals member facilities at the following link.
- Fuchs’ dystrophy. MedlinePlus. http://www.nlm.nih.gov/medlineplus/ency/article/007295.htm . Accessed 5/29/2009.
- Trattler, W. Dystrophy, Lattice. eMedicine. 2006; http://www.emedicine.com/OPH/topic93.htm. Accessed 6/13/2008.
- Sugar, J. Stromal Corneal Dystrophies and Ectasias. In: Yanoff et al.,. Yanoff: Ophthalmology, 2nd ed.. St. Louis, MO : Mosby, Inc; 2004;