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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Majeed syndrome


Other Names for this Disease

  • CDA and CRMO
  • Chronic recurrent multifocal osteomyelitis, congenital
  • Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis
  • Dyserythropoietic anemia, and neutrophilic dermatosis
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Cause

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What causes Majeed syndrome?

Majeed syndrome is caused by mutations in the LPIN2 gene. This gene provides instructions for making a protein called lipin-2. Researchers believe that this protein may play a role in the processing of fats. It may also be involved in controlling inflammation and play a role in cell division. Mutations in the LPIN2 gene alter the structure and function of lipin-2. It is unclear how these genetic changes lead to bone disease, anemia, and inflammation of the skin in people with Majeed syndrome.[1]
Last updated: 10/31/2013

References
  1. Majeed syndrome. Genetics Home Reference (GHR). August 2009; http://ghr.nlm.nih.gov/condition/majeed-syndrome. Accessed 10/31/2013.


Other Names for this Disease
  • CDA and CRMO
  • Chronic recurrent multifocal osteomyelitis, congenital
  • Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis
  • Dyserythropoietic anemia, and neutrophilic dermatosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.