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Majeed syndrome

Other Names for this Disease
  • CDA and CRMO
  • Chronic recurrent multifocal osteomyelitis, congenital
  • Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis
  • Dyserythropoietic anemia, and neutrophilic dermatosis
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What are the symptoms of Majeed syndrome?

Majeed syndrome is characterized by recurrent episodes of fever and inflammation in the bones and skin. There are two main features of Majeed syndrome:[1]
  • Chronic recurrent multifocal osteomyelitis (CRMO), an inflammatory bone condition which causes recurrent episodes of pain and joint swelling. These symptoms begin in infancy or early childhood and typically persist into adulthood, although there may be short periods of improvement. CRMO can lead to complications such as slow growth and the development of joint deformities called contractures, which restrict the movement of certain joints.
  • Congenital dyserythropoietic anemia is a blood disorder which involve a shortage of red blood cells. Without enough of these cells, the blood cannot carry an adequate supply of oxygen to the body's tissues. The resulting symptoms can include tiredness (fatigue), weakness, pale skin, and shortness of breath. Complications of congenital dyserythropoietic anemia can range from mild to severe.

Most people with Majeed syndrome also develop inflammatory disorders of the skin, most often a condition known as Sweet syndrome. The symptoms of Sweet syndrome include fever and the development of painful bumps or blisters on the face, neck, back, and arms.[1]

Last updated: 10/31/2013

  1. Majeed syndrome. Genetics Home Reference (GHR). August 2009; Accessed 10/31/2013.