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Genetic and Rare Diseases Information Center (GARD)

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Majeed syndrome

Other Names for this Disease
  • CDA and CRMO
  • Chronic recurrent multifocal osteomyelitis, congenital
  • Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis
  • Dyserythropoietic anemia, and neutrophilic dermatosis
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How might Majeed syndrome be treated?

Treatment is based upon the symptoms present. Chronic recurrent multifocal osteomyelitis (CRMO) is treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy to avoid disuse atrophy of muscles and contractures. If CRMO does not respond to NSAIDs, corticosteroids can be used short term to control CRMO and skin manifestations. Resolution of bone inflammation has been reported in at least two children who were treated with an IL-1 inhibitor. Congenital dyserythropoietic anemia (CDA) may be treated with red blood cell transfusion.[1]
Last updated: 10/31/2013

  1. El-Shanti H, Ferguson P. Majeed Syndrome. GeneReviews. March 14, 2013; Accessed 10/31/2013.

Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.