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Other Names for this Disease
- Cutaneous leiomyomata with uterine leiomyomata
- Leiomyoma, hereditary multiple, of skin
- Leiomyoma, multiple cutaneous
- Multiple cutaneous and uterine leiomyomata
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 In some families aggressive kidney cancer also occurs as part of the complex and is termed as hereditary leiomyomatosis and renal cell cancer (HLRRC). The complex is often referred to as MCUL/HLRRC (multiple cutaneous and uterine leiomyomatosis/hereditary leiomyomatosis and renal cell cancer) in the medical literature. The cause of both MCUL and HLRCC is a gene called fumarate hydratase (FH), an enzyme involved in the making of energy for the body. MCUL is inherited in an autosomal dominant pattern, which means that a person needs to inherit only one mutated copy of the FH gene to have symptoms of the condition. The symptoms vary from person to person, even within a family. Treatment is based on the person's specific symptoms.Reed syndrome, also called multiple cutaneous and uterine leiomyomatosis (MCUL or MCUL1), is a genetic condition in which people develop benign (non-cancerous) tumors containing smooth muscle tissue (leiomyomas) in the skin and, if female, also in the uterus.
Last updated: 7/6/2009
- Hereditary leiomyomatosis and renal cell cancer. Genetics Home Reference. April 2008; http://ghr.nlm.nih.gov/condition=hereditaryleiomyomatosisandrenalcellcancer. Accessed 6/30/2009.
- Bayley J, Launonen V, Tomlinson IPM. BMC Medical Genetics. 2008; http://www.biomedcentral.com/1471-2350/9/20. Accessed 6/30/2009.
- Genetics Home Reference (GHR) contains information on Reed syndrome. This website is maintained by the National Library of Medicine.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Reed syndrome. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Reed syndrome. Click on the link to view a sample search on this topic.