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Genetic and Rare Diseases Information Center (GARD)

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Mastocytic enterocolitis

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Your Question

I have just been diagnosed by my GI doctor. I have all of the symptoms, even the "nondigestive" ones. I have also had a terrible time with multiple mouth ulcers at a time (so many that eating and talking have been difficult). I didn't see this listed among the symptoms, but am wondering if it could be related as well.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What are the signs and symptoms of mastocytic enterocolitis?

According to the medical literature, signs and symptoms of mastocytic enterocolitis primarily include chronic, intractable diarrhea and abdominal pain. Other symptoms that have occasionally been reported include constipation, nausea, and/or vomiting.[1]

Although other signs and symptoms appear to have been reported by individuals on various online forums and support Web sites, we were unable to locate additional information about symptoms of the condition in the available medical literature. At this time, literature about mastocytic enterocolitis is scarce.
Last updated: 8/6/2013

Are mouth ulcers a symptom of mastocytic enterocolitis?

A search of the limited available medical literature does not yield information about mouth ulcers being a documented symptom of mastocytic enterocolitis. Some individuals stating they have been diagnosed with this condition appear to have reported having mouth ulcers on some online forums and support Web sites; however, we are unable to confirm the validity of these reports. Mouth sores have been reported by individuals with mastocytosis, a related condition in which there is an overabundance of mast cells in the skin and/or other organs of the body.[2]

Individuals with questions or concerns about their signs and symptoms, and whether they are related to a specific diagnosis, should speak with a health care professional.
Last updated: 8/7/2013