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Mastocytic enterocolitis

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Mastocytic enterocolitis is a term describing the condition of chronic, intractable diarrhea in individuals with normal colon or duodenum biopsy results, but with an increased number of mast cells in the colonic mucosa (the innermost layer of the colon).[1] The increase in mast cells is not associated with systemic or cutaneous mastocytosis.[2] It is unclear whether the accumulation of mast cells is a response to, or cause of, the mucosal inflammation that causes the symptoms of the condition.[1] Most individuals with this condition respond well to drugs affecting mast cell function.[2]
Last updated: 8/6/2013


  1. Ogilvie-McDaniel C, Blaiss M, Osborn FD, Carpenter J. Mastocytic enterocolitis: a newly described mast cell entity. Ann Allergy Asthma Immunol. December 2008; 101(6):645-646.
  2. Jakate S, Demeo M, John R, Tobin M, Keshavarzian A.. Mastocytic enterocolitis: increased mucosal mast cells in chronic intractable diarrhea. Arch Pathol Lab Med. 2006 Mar; Accessed 9/19/2012.
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Basic Information

  • The Centers for Disease Control and Prevention (CDC) provides information on chronic diarrhea. The CDC is recognized as the lead federal agency for developing and applying disease prevention and control, environmental health, and health promotion and education activities designed to improve the health of the people of the United States.

In Depth Information

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