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Genetic and Rare Diseases Information Center (GARD)

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Selective IgA deficiency


Other Names for this Disease

  • Gamma-A-globulin, selective deficiency of
  • IgA, selective deficiency of
  • IGAD1
  • Immunoglobulin A deficiency 1
  • Immunoglobulin A, selective deficiency of
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Overview

Selective IgA deficiency refers to the complete or severe deficiency of IgA. This deficiency makes one more prone to infections, allergies, diarrhea, and autoimmune diseases. It is the most common type of primary immunodeficiency and is caused by a lack of mature B-lymphocytes. Why the B-lymphocytes fail to mature and produce IgA is not clear. Familial occurrence has been reported in the medical literature, some cases were suggestive of autosomal dominant inheritance, others of autosomal recessive inheritance.[1]
Last updated: 8/19/2009

References

  1. Selective IgA deficiency. Primary Immunodeficiency Resource Center. http://www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=syndromes&area=2&CFID=34984195&CFTOKEN=54477486. Accessed 8/19/2009.
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Please contact us with your questions about Selective IgA deficiency. We will answer your question and update these pages with new resources and information.

Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute of Allergy and Infectious Diseases (NIAID) provides information on the immune system and immune system diseases. The NIAID supports research to develop better ways to diagnose, treat, and prevent infectious, immunologic, and allergic diseases.
  • The National Primary Immunodeficiency Resource Center has an information page on this topic. Click on the link above to view the information page.
  • The Immune Deficiency Foundation has a patient and family handbook on primary immunodeficiency diseases. Click on the link above to view this resource.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Selective IgA deficiency. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Gamma-A-globulin, selective deficiency of
  • IgA, selective deficiency of
  • IGAD1
  • Immunoglobulin A deficiency 1
  • Immunoglobulin A, selective deficiency of
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.