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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Neu Laxova syndrome


Other Names for this Disease
  • NLS
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Inheritance


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How is Neu-Laxova syndrome inherited?

Neu-Laxova is inherited in an autosomal recessive manner.[1] Both parents would need to carry one copy of the mutated gene for the condition in order to have a child with Neu-Laxova.  For an individual that has a sibling with Neu-Laxova, the chance of being of carrier is 2/3.  Two carriers have a 1 in 4 (25%) chance with each pregnancy of having a child affected by the condition. We strongly recommend you discuss your concerns with a genetics professional to determine your specific risks of being a carrier and having a child with this condition.
Last updated: 8/1/2012

References
  1. Manning MA, Cunniff CM, Colby CE. Neu-Laxova syndrome: detailed prenatal diagnostic and post-mortem findings and literature review. Am J Med Genet. 2004; 3:240-9. http://www.ncbi.nlm.nih.gov/pubmed/14994231. Accessed 8/1/2012.