* Not a rare disease
Other Names for this Disease
- Granulomatous colitis
- Granulomatous enteritis
What are the signs and symptoms of Crohn's disease?
What causes Crohn's disease?
Is Crohn's disease inherited?
How is Crohn's disease diagnosed?
How might Crohn's disease be treated?
About one-third of individuals with Crohn's disease have symptoms outside of the intestines, which may include arthritis, uveitis (inflammation of the covering of the eye), skin lesions, and sacroilitis (inflammation of the large joints of the tail bone and pelvis).
Symptoms of Crohn's disease may range from mild to severe. Most people will go through periods in which the disease flares up and causes symptoms, alternating with periods when symptoms disappear or decrease. People with Crohn’s disease who smoke tend to have more severe symptoms and more complications. In general, people with Crohn's disease lead active and productive lives.
Recent studies have found that variations in specific genes, including the ATG16L1, IL23R, IRGM, and NOD2 genes, influence the risk of developing Crohn's disease. These genes provide instructions for making proteins that are involved in immune system function. Variations in any of these genes may disrupt the ability of intestinal cells to respond to bacteria, leading to chronic inflammation and thus the signs and symptoms of the condition. There may also be genetic variations in regions of chromosome 5 and chromosome 10 that contribute to an increased risk to develop Crohn's disease.
For information on the treatment of Crohn's disease, visit the following links:
National Digestive Diseases Information Clearinghouse:
Crohn's & Colitis Foundation of America:
Complementary and Alternative Medicine (CAM) for Crohn's disease from the Crohn's & Colitis Foundation of America:
- Crohn's disease. National Digestive Diseases Information Clearinghouse (NIDDC). 2006; http://digestive.niddk.nih.gov/ddiseases/pubs/crohns/index.htm. Accessed 7/29/2010.
- David B. Sachar, Aaron E. Walfish. Crohn's Disease. Merck Manuals. Aigust 2006; http://www.merckmanuals.com/home/digestive_disorders/inflammatory_bowel_diseases_ibd/crohns_disease.html?qt=&sc=&alt=.
- Crohn disease. Genetics Home Reference. August 2007; http://ghr.nlm.nih.gov/condition/crohn-disease. Accessed 10/15/2012.
- Cummings S, Rubin D. The Complexity and Challenges of Genetic Counseling and Testing for Inflammatory Bowel Disease. Journal of Genetic Counseling. December 2006;
- What are complex or multifactorial disorders?. Genetics Home Reference. October 8, 2012; http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/complexdisorders. Accessed 10/15/2012.
- Department of Human Genetics. Autoimmune disorders. Emory University School of Medicine. 2004; http://www.genetics.emory.edu/pdf/Emory_Human_Genetics_Autoimmune_Disorders.pdf. Accessed 2/7/2012.
- Crohn Disease. Genetics Home Reference (GHR) . August 2007; http://ghr.nlm.nih.gov/condition=crohndisease. Accessed 2/7/2012.
- Diagnosing Crohn's Disease and Ulcerative Colitis. Crohn's & Colitis Foundation of America. May 31, 2010; http://www.ccfa.org/resources/diagnosing-crohns-uc.html. Accessed 10/15/2012.