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Genetic and Rare Diseases Information Center (GARD)

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Crohn's disease

*

* Not a rare disease

Other Names for this Disease

  • Enteritis
  • Granulomatous colitis
  • Granulomatous enteritis
  • Ileitis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

Where can I get a complete list of all genes that have been associated with Crohn's disease?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What genes are currently known to be associated with Crohn's disease?

More than 30 distinct genes, or presumed locations of genes (loci), have been suggested to be related to CD, including those related to susceptibility, age of onset, disease location, diagnosis, and prognosis.[1] So far, the strongest associations with CD have been found with the NOD2 (also called CARD15), IL23R and ATG16L1 genes.[1]

The search for specific susceptibility genes (genes in which variations may increase a person's risk) has been difficult due to complex genetics, including factors such as the lack of simple inheritance patterns and involvement of several genes. Studies have already led to the identification of a number of susceptibility genes: NOD2, DLG5, OCTN1 (also called SLC22A4), OCTN2 (SLC22A5), NOD1, IL23R, PTGER4, ATG16L1 and IRGM. The NOD2 gene is currently the most replicated and understood.[1]

With respect to age of CD onset and more specifically to childhood or early-onset Crohn’s disease, the following genes/loci have been implicated: TNFRSF6B, CXCL9, IL23R, NOD2, ATG16L1 rs2241880, CNR1, IL-10, and MDR1 (also called ABCB1).[1]

In terms of genes related to CD location, studies have suggested that upper GI Crohn’s disease has been related to NOD2 and MIF variants. Ileal CD has been related to the IL-10, CRP, NOD2, ZNF365 and STAT3 genes. Genes/loci associated with ileocolonic CD are 3p21, ATG16L1 and TCF-4 (TCF7L2).[1]

Variations in a number of genes have also been found to be associated with other aspects of CD, such as disease behavior, risk for cancer, and presence of extraintestinal manifestations.[1] To view a free, full-text journal article published in 2012 about the role of genetics in CD, click here. To view only a table from this article listing the genes that appear to be associated with Crohn's disease, click here.

Because the information provided here is complex, individuals seeking to better understand this information may benefit from meeting with a genetics professional or other qualified health care provider.
Last updated: 10/16/2012

How can I find a genetics professional in my area?

Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:
Last updated: 6/5/2014

References
  • Tsianos EV, Katsanos KH, Tsianos VE. Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol. January 14, 2012; 18(2):105-118.
Other Names for this Disease
  • Enteritis
  • Granulomatous colitis
  • Granulomatous enteritis
  • Ileitis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.