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About one-third of individuals with Crohn's disease have symptoms outside of the intestines, which may include arthritis, uveitis (inflammation of the covering of the eye), skin lesions, and sacroilitis (inflammation of the large joints of the tail bone and pelvis).
Symptoms of Crohn's disease may range from mild to severe. Most people will go through periods in which the disease flares up and causes symptoms, alternating with periods when symptoms disappear or decrease. People with Crohn’s disease who smoke tend to have more severe symptoms and more complications. In general, people with Crohn's disease lead active and productive lives.
The Human Phenotype Ontology provides the following list of signs and symptoms for Crohn's disease. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.
The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.
The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.
Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.
- Crohn's disease. National Digestive Diseases Information Clearinghouse (NIDDC). 2006; http://digestive.niddk.nih.gov/ddiseases/pubs/crohns/index.htm. Accessed 7/29/2010.
- Crohn disease. Genetics Home Reference. August 2007; http://ghr.nlm.nih.gov/condition/crohn-disease. Accessed 10/15/2012.
- Cummings S, Rubin D. The Complexity and Challenges of Genetic Counseling and Testing for Inflammatory Bowel Disease. Journal of Genetic Counseling. December 2006;