Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Monogenic diabetes

*


* Not a rare disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview


The most common forms of diabetes, type 1 and type 2, are polygenic, meaning the risk of developing these forms of diabetes is related to multiple genes [1][2]. Environmental factors, such as obesity in the case of type 2 diabetes, also play a part in the development of polygenic forms of diabetes. Polygenic forms of diabetes often run in families. Doctors diagnose polygenic forms of diabetes by testing blood glucose in individuals with risk factors or symptoms of diabetes [1].

Some rare forms of diabetes result from mutations in a single gene and are called monogenic [1][2]. Monogenic forms of diabetes may account for about 1 to 5 percent of all cases of diabetes in young people [1]. In some cases of monogenic diabetes, the gene mutation is inherited; but in others, the gene mutation develops spontaneously [1][2]. Most mutations in monogenic diabetes reduce the body's ability to produce insulin, a protein produced in the pancreas that is essential for the body to use glucose for energy [1][2]. As a result, monogenic diabetes can easily be mistaken for type 1 diabetes [2].

Last updated: 9/23/2011

References

  1. Monogenic Forms of Diabetes Mellitus: Neonatal Diabetes Mellitus and Maturity-onset Diabetes of the Young. National Diabetes Information Clearinghouse (NDIC). March 2007; http://diabetes.niddk.nih.gov/dm/pubs/mody/. Accessed 8/14/2008.
  2. What is Monogenic Diabetes? . The University of Chicago Kovler Diabetes Center. http://www.monogenicdiabetes.org/what-is-monogenic-diabetes. Accessed 9/23/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

2 question(s) from the public on Monogenic diabetes have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • The National Diabetes Information Clearinghouse (NDIC) was established in 1978 to increase knowledge and understanding about diabetes among patients, health care professionals, and the general public. Click on the link to view information on this topic. 

In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Monogenic diabetes. Click on the link to view a sample search on this topic.