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Genetic and Rare Diseases Information Center (GARD)

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Hereditary cerebral hemorrhage with amyloidosis


Other Names for this Disease
  • Hereditary cerebral hemorrhage with amyloidosis, Dutch type (subtype)
  • Hereditary cerebral hemorrhage with amyloidosis, Icelandic type (subtype)
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Your Question

My father as well as several other family members had cerebral amyloid angiopathy (CAA).  What are my chances of having the condition?  What is the difference between familial CAA and Dutch type CAA?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is cerebral amyloid angiopathy (CAA)?

Cerebral amyloid angiopathy (CAA) is a neurological condition in which amyloid protein is deposited onto the walls of the arteries of the brain (and less frequently, veins).  Although CAA often does not cause symptoms, it may cause bleeding into the brain (hemorrhagic stroke), dementia, or neurologic episodes in some patients.  The majority of CAA cases occur in individuals who do not have a family history. However, two familial forms of CAA have been identified. [1][2]
Last updated: 2/5/2009

What is the difference between "familial" cerebral amyloid angiopathy and cerebral amyloid angiopathy, Dutch type?

"Familial" cerebral amyloid angiopathy is another term often used to refer to hereditary cerebral hemorrhage with amyloidosis. Hereditary cerebral hemorrhage with amyloidosis is the term more commonly used in the medical literature. Hereditary cerebral hemorrhage with amyloidosis, Dutch type is a specific form of hereditary cerebral hemorrhage with amyloidosis that is caused by a mutation (genetic change) in the APP (amyloid precursor protein) gene. There is at least one other form of hereditary cerebral hemorrhage with amyloidosis: the "Icelandic type," which is due to a mutation in the cystatin C gene.[3]
Last updated: 7/19/2013

Since I have a family history of hereditary cerebral hemorrhage with amyloidosis, what are the chances that I inherited the condition?

To find out your chances of having hereditary cerebral hemorrhage with amyloidosis, you may want to speak with a genetics professional. A genetics professionl can review your medical and family history in order to provide you with your specific risks. To learn more about genetic consultations, click here.
Last updated: 7/19/2013

How can I find a genetics professional in my area?

Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:

Last updated: 1/21/2014

References