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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Diabetes mellitus type 1

*

* Not a rare disease

Other Names for this Disease

  • Diabetes mellitus, insulin dependent
  • IDDM
  • Insulin-dependent diabetes mellitus
  • Juvenile-onset diabetes
  • Type 1 diabetes
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body.[1]
Last updated: 4/25/2014

References

  1. Type 1 diabetes. Genetics Home Reference. March, 2013; http://ghr.nlm.nih.gov/condition/type-1-diabetes. Accessed 4/25/2014.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Diabetes mellitus type 1 have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • The American College of Obstetricians and Gynecologists (ACOG) created a publication on birth defects.  The pamphlet discusses ways in which a woman can decrease her chances of having a baby with a birth defect, including women who are pregnant and have diabetes. To read more about birth defects, visit the link below.
    Link: http://www.acog.org/publications/patient_education/bp146.cfm?printerFriendly=yes
  • Genetics Home Reference contains information on Diabetes mellitus type 1. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Diabetes Information Clearinghouse (NDIC) was established in 1978 to increase knowledge and understanding about diabetes among patients, health care professionals, and the general public. Click on the link to view information on this topic. 

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Diabetes mellitus type 1. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Diabetes mellitus, insulin dependent
  • IDDM
  • Insulin-dependent diabetes mellitus
  • Juvenile-onset diabetes
  • Type 1 diabetes
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.