Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Congenital disorders of glycosylation

Other Names for this Disease
  • Carbohydrate-deficient glycoprotein syndromes
  • CDG
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Congenital disorders of glycosylation (CDG) are a group of inherited metabolic disorders that affect a process called glycosylation. Glycosylation is the complex process by which all human cells build long sugar chains that are attached to proteins, which are called glycoproteins. There are many steps involved in this process, and each step is triggered by a type of protein called an enzyme. Individuals with a CDG are missing one of the enzymes that is required for glycosylation. The type of CDG that a person has depends on which enzyme is missing. Currently, there are 19 identified types of CDG.[1] CDG type IA is the most common form. The symptoms of CDG vary widely among affected individuals. Some people have severe developmental delay, failure to thrive, and multiple organ problems, while others have diarrhea, low blood sugar (hypoglycemia), liver problems, and normal developmental potential.[2]
Last updated: 9/21/2011


  1. About CDG. The CDG Family Network. August 2010; Accessed 9/21/2011.
  2. Sparks E, Krasnewich DM. Congenital Disorders of Glycosylation Overview. GeneReviews . August 2011; Accessed 9/21/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Congenital disorders of glycosylation have been answered. See questions and answers. You can also submit a new question.
On this page

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Congenital disorders of glycosylation. Click on the link to view a sample search on this topic.