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* Not a rare disease
* Not a rare disease
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Scleroderma is a group of widespread connective tissue diseases that involve changes in the skin, blood vessels, muscles, and internal organs. There are two main types. Localized scleroderma affects only the skin. Systemic scleroderma affects the blood vessels and internal organs, as well as the skin. Although the cause of scleroderma is unknown, it is believed to be related to an overproduction and accumulation of collagen which results when the immune system turns against the body (autoimmune reaction). There is no cure, but various treatments can relieve symptoms.
- Borigini MJ. Scleroderma. MedlinePlus. http://www.nlm.nih.gov/medlineplus/ency/article/000429.htm. Accessed October 11, 2010.
- Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). http://www.niams.nih.gov/Health_Info/Scleroderma/default.asp. Accessed October 11, 2010.
- Scleroderma. MayoClinic.com. http://www.mayoclinic.com/print/scleroderma/DS00362/DSECTION=all&METHOD=print. Accessed October 11, 2010.
- MedlinePlus, a Web site designed by the National Library of Medicine to help you research your health questions, provides more information about this topic. Click on the link to view this information.
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Scleroderma. Click on the link to go to OMIM and review these resources.
Selected Full-Text Journal Articles
- Select volumes of the Scleroderma Care and Research Jounal can be viewed by visiting the Scleroderma Clinical Trials Consortium Web site. Click on the link above to learn more.