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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Diffuse gastric cancer


Other Names for this Disease

  • Signet cell adenocarcinoma
  • Signet ring cell carcinoma
  • Signet ring cell gastric carcinoma
  • Signet ring gastric carcinoma
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Inheritance

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Can diffuse gastric cancer be inherited?

Diffuse gastric cancer can be inherited or can happen sporadically in a family. Sporadic means that the cancer occurred randomly for the first time in a individual and was not inherited from a parent. Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the CDH1 gene. Individuals with a CDH1 mutation typically develop cancer before age 40.[1]
Last updated: 12/16/2011

References
  1. Kaurah P, Huntsman DG. Hereditary diffuse gastric cancer. GeneReviews. June 2011; http://www.ncbi.nlm.nih.gov/books/NBK1139/. Accessed 9/30/2011.


Other Names for this Disease
  • Signet cell adenocarcinoma
  • Signet ring cell carcinoma
  • Signet ring cell gastric carcinoma
  • Signet ring gastric carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.