Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Gamma heavy chain disease


Other Names for this Disease
  • Franklin disease
  • Gamma heavy chain deposition disease
  • IgG heavy chain disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview


Gamma heavy chain disease is characterized by the abnormal production of antibodies.[1] Antibodies are made up of light chains and heavy chains. In this disorder, the heavy chain of the gamma antibody (IgG) is overproduced by the body.  Gamma heavy chain disease mainly affects older adults and is similar to aggressive malignant (cancerous) lymphoma.[2] However, some people with this disorder have no symptoms. People with symptoms may respond to chemotherapy drugs, corticosteroids, and radiation therapy.[3] Approximately one-third of individuals with gamma heavy chain disease are also diagnosed with an autoimmune disorder.[1]
Last updated: 7/25/2010

References

  1. Brick W, Faguet GB, Burgess R. Heavy Chain Disease, Gamma. eMedicine Journal. April 15, 2009; http://emedicine.medscape.com/article/200675-overview. Accessed 7/25/2010.
  2. Heavy chain diseases. Merck Manual for Healthcare Professionals. July 2008; http://www.merck.com/mmpe/sec11/ch144/ch144b.html. Accessed 7/25/2010.
  3. Heavy chain diseases. Merck Manuals Online Medical Library. July 2008; http://www.merck.com/mmhe/sec14/ch175/ch175e.html. Accessed 7/25/2010.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Gamma heavy chain disease have been answered. See questions and answers. You can also submit a new question.

Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Merck Manual for Healthcare Professionals provides more detailed information on heavy chain diseases.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Gamma heavy chain disease. Click on the link to view a sample search on this topic.