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Lymphocytic hypophysitis

Other Names for this Disease
  • Autoimmune hypophysitis
  • LH
  • LYH
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Lymphocytic hypophysitis (LH) is a condition in which the pituitary gland becomes infiltrated by lymphocytes, resulting in pituitary enlargement and impaired function.[1][2] It most often occurs in women in late pregnancy or the postpartum period, but can also occur in prepubertal or post-menopausal women, and in men.[1][2] Symptoms of LH may include headache, visual field impairment and more rarely, double vision (diplopia).[1] The exact cause is unknown but is thought to be autoimmune-related.[2][1] Although some cases resolve on their own or after a short course of steroids, other cases cause persistent problems even with aggressive medical or surgical treatment.[3]
Last updated: 10/1/2012


  1. Antonio Bellastella, Antonio Bizzarro, Concetta Coronella, Giuseppe Bellastella, Antonio Agostino Sinisi and Annamaria De Bellis. Lymphocytic hypophysitis: a rare or underestimated disease?. European Journal of Endocrinology. 2003; 149:363-376.
  2. Peter J Snyder, MD. Causes of Hypopituitarism. UpToDate. Waltham, MA: UpToDate; 2012;
  3. Schreckinger M, Francis T, Rajah G, Jagannathan J, Guthikonda M, Mittal S. Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab. J Neurosurg. June 2012;
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