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Genetic and Rare Diseases Information Center (GARD)

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Immunoglobulin G deficiency


* Not a rare disease
Other Names for this Disease
  • IgG deficiency
  • IgG subclass deficiency
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Immunoglobulin G (IgG) deficiency is a condition that involves the immune system and is characterized by a shortage of type G antibodies.[1] There are four different subclasses of IgG: IgG1, IgG2, IgG3, and IgG4. People with IgG deficiency may have a decreased amount of one or more of the IgG subclasses. When people also have a shortage of other types of antibodies, they are said to have a combined immunodeficiency. Individuals with IgG deficiency may have an increased susceptibility to infection, but the symptoms of this condition are variable.[2] Some people never experience any symptoms. Treatment may involve antibiotics and intravenous (IV) immunoglobulin.[2]
Last updated: 11/11/2008


  1. Vafaie J. Immunoglobulin G deficiency. eMedicine Journal. Mar 22, 2005; Accessed 11/11/2008.
  2. IgG Subclass Deficiency. National Primary Immunodeficiency Resource Center. Accessed 11/11/2008.
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