Print friendly version
Other Names for this Disease
- Trehalose intolerance
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 Individuals with this deficiency experience vomiting, abdominal discomfort and diarrhea after eating foods containing trehalose. Studies suggest that this condition is very rare in white Americans, very frequent in Greenland natives (where it has been reported in 8% of the population), and not infrequent among Finns. However, since ingestion of large quantities of foods containing trehalose in not common, the real frequency in unknown. Most cases appear to be inherited in an autosomal recessive manner.Trehalase deficiency is a metabolic condition in which the body is not able to convert trehalose, a disaccharide found in mushrooms, algae and insects, into glucose.
Last updated: 2/4/2010
- Murray IA, Coupland K, Smith JA, Ansell ID, Long RG. British Journal of Nutrition. 2000; http://journals.cambridge.org/action/displayFulltext?type=1&fid=880176&jid=BJN&volumeId=83&issueId=03&aid=880164. Accessed 2/4/2010.
- Semenza G, Auricchio S, Mantei N. Chapter 75 - Small Intestinal Disaccharidoses. The Metabolic & Molecular Bases of Inherited Disease, 8th ed. New York: McGraw-Hill; 2001;
- Abbott PJ, Chen J. WHO Food Additives Series 46: Trehalose. International Programme on Chemical Safety. http://www.inchem.org/documents/jecfa/jecmono/v46je05.htm. Accessed 2/4/2010.
- Kleinman RE, Goulet O, Mieli-Vergani G, Sherman PM. Walker's Pediatric Gastrointestinal Disease: Physiology, Diagnosis, Management, 5th edition. 2008;
- Trehalase Deficiency. Online Mendelian Inheritance in Man (OMIM). 2008; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=612119. Accessed 2/4/2010.
- Swallow DM, Poulter M, Hollox EJ. Drug Metabolism and Disposition. 2001; http://dmd.aspetjournals.org/content/29/4/513.full. Accessed 2/4/2010.
Your Questions Answeredby the Genetic and Rare Diseases Information Center
Please contact us with your questions about Trehalase deficiency. We will answer your question and update these pages with new resources and information.
On this page
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Trehalase deficiency. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Trehalase deficiency. Click on the link to view a sample search on this topic.