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Diseases

Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation
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Cause


Newline Maker

What causes rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD)?

The exact cause of ROHHAD is unknown at this time. Several genes, namely the PHOX2B gene, the BDNF gene, and the TRKB gene (also called the NTRK2 gene), have been ruled out after consideration based on overlapping symptoms seen with ROHHAD, congenital central hypoventilation syndrome (CCHS), and preliminary animal studies.[1]
Last updated: 11/28/2011

References
  1. Ize-Ludlow D, Gray JA, Sperling MA, Berry-Kravis EM, Milunsky JM, Farooqi IS, Rand CM, Weese-Mayer DE. Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood. Pediatrics. July 2007; http://pediatrics.aappublications.org/cgi/content/full/120/1/e179. Accessed 11/28/2011.