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Goblet cell carcinoma

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Overview


Goblet cell carcinoma is a type of neuroendocrine tumor that develops from goblet cells.  Goblet cells are cells that line internal organs and make mucus.  Goblet cell carcinoma most commonly develops in the digestive tract, particularly in the appendix. The first symptom of goblet cell carcinoma is often appendicitis, or sometimes lasting pain and an unusual mass in the lower right abdomen. In general, approximately 76% of individuals diagnosed with a goblet cell tumor are alive five years after their diagnosis.  An important predictor of survival is the initial size of the tumor and whether or not tumor cells have spread from its original location to other parts of the body.[1][2]  Treatment begins with surgery and may include chemotherapy in some cases.[2]

References

  1. Plöckinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, de Herder WW, Gross D, Knapp WH, Knigge UP, Kulke MH, Pape UF; Frascati. Consensus Conference participants. Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology. Epub 2007 Oct 11 -7.
  2. Roy P, Chetty R. Goblet cell carcinoid tumors of the appendix: An overview. World Journal of Gastrointestinal Oncology. 2010. http://www.ncbi.nlm.nih.gov/pubmed/21160637. Accessed March 21, 2012.
  3. Modlin IM, Kidd M, Latich I, Zikusoka MN, Eick GN, Mane SM, Camp RL. Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed. Ann Surg. 2006 Jul.
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General Information

  • The American Cancer Society has an information page on gastrointestinal carcinoid tumor. Click on American Cancer Society to view the information page.
  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.  Click on the link to view information on this topic. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.  Click on the link to read information on this topic.
  • The Carcinoid Cancer Foundation, Inc. has an information page on carcinoid tumors and related neuroendocrine tumors. Click on Carcinoid Cancer Foundation, Inc. to view the information page.