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Your QuestionHow is neurofibromatosis inherited?
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Neurofibromatosis is inherited in an autosomal dominant manner. This means that to be affected, a person only needs a change (mutation) in one copy of the responsible gene in each cell. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene. These cases occur in people with no history of the disorder in their family. A person with neurofibromatosis has a 50% chance with each pregnancy of passing along the altered gene to his or her child.
Last updated: 12/1/2014
- Learning About Neurofibromatosis. National Human Genome Research Institute. March 2014; http://www.genome.gov/14514225.