Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • CASIL
  • Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
  • Dementia, hereditary multi-infarct type
  • Familial vascular leukoencephalopathy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Prognosis


Newline Maker

What is the prognosis for individuals with CADASIL?

Symptoms usually progress slowly. By age 65, the majority of persons with CADASIL have severe cognitive problems and dementia. Some people lose the ability to walk and most become completely dependent due to multiple strokes.[1]

Data on the long-term prognosis come from a large study of 411 individuals, which found that the median age at onset of inability to walk without assistance was 60 years and the median age at onset of being bedridden was 64 years. The median age at death was 68 years with a more rapid disease progression in men than in women. At their time of death, 78% of individuals were completely dependent and 63% were confined to bed. Pneumonia was the most frequent cause of death.[2]
Last updated: 3/22/2011

References
  1. NINDS CADASIL Information Page. National Institute of Neurological Disorders and Stroke (NINDS). October 13, 2009; http://www.ninds.nih.gov/disorders/cadasil/CADASIL.htm. Accessed 3/22/2011.
  2. Lesnik Oberstein SAJ, Boom EMJ, Dichgans M. CADASIL. GeneReviews. July 23, 2009; http://www.ncbi.nlm.nih.gov/books/NBK1500/. Accessed 3/22/2011.