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Craniorachischisis is the most severe type of neural tube defect in which both the brain and spinal cord remain open; both anencephaly and spina bifida (from the cervical region to the lumbar or sacral region of the spine) are present.[1][2] Fetuses with craniorachischisis often miscarry during pregnancy or die shortly after birth.[2] The cause is thought to be multifactorial, which means that a combination of genetic and non-genetic factors play a role.[1]
Last updated: 11/5/2013


  1. Craniorachischisis. Orphanet. January, 2010; Accessed 11/4/2013.
  2. Johnson KM, Suarez L, Felkner MM, Hendricks K. Prevalence of craniorachischisis in a Texas-Mexico border population. Birth Defects Res A Clin Mol Teratol. February, 2004; 70(2):92-94. Accessed 11/5/2013.
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