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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Craniorachischisis


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Overview


Craniorachischisis is the most severe type of neural tube defect in which both the brain and spinal cord remain open; both anencephaly and spina bifida (from the cervical region to the lumbar or sacral region of the spine) are present.[1][2] Fetuses with craniorachischisis often miscarry during pregnancy or die shortly after birth.[2] The cause is thought to be multifactorial, which means that a combination of genetic and non-genetic factors play a role.[1]
Last updated: 11/5/2013

References

  1. Craniorachischisis. Orphanet. January, 2010; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=63260. Accessed 11/4/2013.
  2. Johnson KM, Suarez L, Felkner MM, Hendricks K. Prevalence of craniorachischisis in a Texas-Mexico border population. Birth Defects Res A Clin Mol Teratol. February, 2004; 70(2):92-94. Accessed 11/5/2013.
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In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Craniorachischisis. Click on the link to view a sample search on this topic.