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Trabecular fiber myopathy

Other Names for this Disease
  • Myopathy with lobulated fibers
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Trabecular fiber myopathy (TFM) is a muscle disease that typically begins during adulthood. This condition is characterized by slowly progressive muscle weakness in the upper (proximal) portions of each limb (upper arms and thighs). Affected individuals are often grouped in the general category of limb-girdle muscular dystrophy. Weakness of other muscles may also occur, although people with TFM do not develop eye muscle weakness or cardiomyopathy. Affected individuals may have cramps, fatigue, and high creatine kinase (CK) levels. TFM occurs in both males and females. Most affected individuals do not have a family history of related muscle problems.[1]
Last updated: 8/3/2009


  1. Weller B, Carpenter S, Lochmuller H, Karpati G. Myopathy with trabecular muscle fibers. Neuromuscular Disorders. 1999;
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