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Genetic and Rare Diseases Information Center (GARD)

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Amyloidosis AA


Other Names for this Disease
  • AA Amyloidosis
  • Amyloid A amyloidosis
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Overview


Amyloidosis is a group of diseases in which a protein, called amyloid, builds up in the body's organs and tissues. Amyloidosis AA is also referred to as Secondary amyloidosis or Inflammatory amyloidosis. This disease is caused by a long-lasting infection or inflammatory disease such as rheumatoid arthritis, familial Mediterranean fever, or osteomyelitis. Infection or inflammation in the body causes an increased amount of a specific protein called serum amyloid A (SAA) protein. In this disease, part of the SAA protein forms deposits called "amyloid fibrils". These desposits occur in the space around the cells of certain tissues of the body. Amyloidosis AA usually begins as a disease in the kidneys, but other organs can be affected such as the liver and spleen. Medical or surgical treatment of the underlying infection or inflammatory disease can slow down or stop the progression of this condition.[1][2]
Last updated: 1/3/2014

References

  1. Boston University Amyloidosis Center. Amyloidosis Types. http://www.bu.edu/amyloid/about/what/types/. Accessed 1/3/2014.
  2. R Dhawan, MM Ahmed, E Mubashir et al. AA (Inflammatory) Amyloidosis. Medscape Reference. 10/08/2013; http://emedicine.medscape.com/article/335559-overview. Accessed 1/3/2014.
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Basic Information

  • The Mayo Clinic provides information on the diagnosis and treatment of amyloidosis.
  • Amyloidosis Awareness is an illustrated booklet for patients and physicians developed by Amyloidosis Support Groups Inc. Versions of the booklet are also available in Spanish and Portuguese.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Amyloidosis AA. Click on the link to view a sample search on this topic.