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Teratoma with malignant transformation


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Your Question

I am trying to find out more information about teratomas with malignant transformation, specifically related to prognosis.  I had a single mass removed with clean margins and no infiltration.  Any studies that have been done about treatment options would be helpful.  Also, are there any other published cases of teratoma and astrocytoma?  I guess I am trying to find out if my type of teratoma would portend a better or worse prognosis than other types, especially given how fast mine developed.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What treatments are available for teratoma with malignant transformation?

Because teratoma with malignant transformation (TMT) is quite rare, there are no established treatment guidelines.  In general, treatment often includes surgery to remove as much of the TMT as possible.  Chemotherapy that is specifically designed to target the malignant part of the TMT may also be used.[1][2]
Last updated: 9/21/2012

What is the prognosis for teratoma with malignant transformation?

Prognosis depends on the extent of disease and effectiveness of surgery; it is best when teratomas with malignant transformation (TMTs) have not spread to other parts of the body (metastasized) and when surgery successfully removes all of the tumor cells.[1][3]  One article states that up to 60% of individuals diagnosed with teratoma with malignant transformation are alive five years after diagnosis.  The authors of this article also state that it is not known if the particular type of the malignant component changes prognosis.[1]
Last updated: 9/21/2012

Are there other published cases of teratoma with malignant transformation to astrocytoma?

There are three other published cases of teratoma with malignant transformation to astrocytoma: one man was found to have a testicular teratoma including an astrocytoma component and two girls were found to have ovarian teratomas including an astrocytoma component.[4][5]
Last updated: 9/21/2012

References
  • Athanasiou A, Vanel D, El Mesbahi O, Theodore C, Fizazi K. Non-germ cell tumours arising in germ cell tumours (teratoma with malignant transformation) in men: CT and MR findings. European Journal of Radiology. 2009; 69:230-235. http://www.ncbi.nlm.nih.gov/pubmed/19056194. Accessed 9/20/2012.
  • El Mesbahi O, Terrier-Lacombe MJ, Rebischung C, Theodore C, Vanel D, Fizazi K. Chemotherapy in patients with teratoma with malignant transformation. European Urology. 2007; 51:1306-1311. http://www.ncbi.nlm.nih.gov/pubmed/17081678. Accessed 9/20/2012.
  • Motzer RJ, Amsterdam A, Prieto V, Sheinfeld J, Murty VV, Mazumdar M, Bosl GJ, Chaganti RS, Reuter VE. Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. Journal of Urology. 1998; 159:133-138. http://www.ncbi.nlm.nih.gov/pubmed/9400455. Accessed 9/20/2012.
  • Spiess PE, Pisters LL, Liu P, Pettaway CA, Kamat AM, Gomez JA, Tannir NM. Malignant transformation of testicular teratoma: a chemoresistant phenotype. Urologic Oncology. 2008; 26:595-599. http://www.ncbi.nlm.nih.gov/pubmed/18367105. Accessed 9/20/2012.
  • Biskup W, Calaminus G, Schneider DT, Leuschner I, Göbel U. Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96. Klinische Padiatrie. 2006; 218:303-308. http://www.ncbi.nlm.nih.gov/pubmed/17080331. Accessed 9/20/2012.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.