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Genetic and Rare Diseases Information Center (GARD)

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Bone marrow necrosis


* Not a rare disease
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In bone marrow necrosis, there is poor circulation of oxygen and nutrients to the bone marrow cells, causing the cells to die. Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. Bone marrow necrosis often causes fever and bone pain, and is associated with blood cancers, in particular acute lymphoblastic leukemia (ALL) although it can be associated with other cancers and non-cancerous conditions (e.g., sickle cell anemia, tuberculosis, infection, and sepsis).[1][2][3]
Last updated: 4/8/2010


  1. Paydas S, Ergin M, Baslamisli F, Yavuz S, Zorludemir S, Sahin B, Bolat F. Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature. American Journal of Hematology. 2002;
  2. Matsue K, Takeuchi M, Koseki M, Uryu H. Bone marrow necrosis associated with the use of imatinib mesylate in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. Ann Hematol. 2006;
  3. Inoue S, Monga R, Onwuzurike N. Bone Marrow Necrosis as a presenting feature of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;
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