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Genetic and Rare Diseases Information Center (GARD)

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Bone marrow necrosis


* Not a rare disease
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What are the signs and symptoms of bone marrow necrosis?

Signs and symptoms of bone marrow necrosis, include bone pain, fever, fatigue, and jaundice. The bone pain may be throughout the body or localized to the lower back and/or legs.[1][2][3] Laboratory findings may include anemia, thrombocytopenia, and elevated levels of lactic dehydrogenase and alkaline phosphatase.[1][2]
Last updated: 4/8/2010

  1. Paydas S, Ergin M, Baslamisli F, Yavuz S, Zorludemir S, Sahin B, Bolat F. Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature. American Journal of Hematology. 2002;
  2. Matsue K, Takeuchi M, Koseki M, Uryu H. Bone marrow necrosis associated with the use of imatinib mesylate in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. Ann Hematol. 2006;
  3. Inoue S, Monga R, Onwuzurike N. Bone Marrow Necrosis as a presenting feature of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;