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Genetic and Rare Diseases Information Center (GARD)

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Niemann-Pick disease type B

Other Names for this Disease
  • Niemann Pick disease type B
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Your Question

I have Niemann-Pick disease type B. I have always had trouble with cellulite, even in childhood. Are these conditions related?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is Niemann-Pick disease type B and cellulite related?

Currently, we are not aware of an association between Niemann-Pick disease type B and cellulite.  People with Niemann-Pick disease have an abnormal lipid (fat) metabolism which causes lipids to build-up in the spleen, lung, liver, bone marrow, and brain. Signs and symptoms may include enlarged liver and spleen, reduced growth, elevated levels of cholesterol and other fats, and reduced numbers of blood cells involved in clotting (platelets).[1]

Cellulite is often found in the pelvis, thighs, and abdomen. It is estimated to affect 85% to 95% of women.[2] According to a recent review article on cellulite by Khan MH et al., 2010, cellulite is thought to result from the "herniation of subcutaneous fat within fibrous connective tissue."  The underlying cause for this herniation is not well understood, and is likely multifaceted.

You can read more about cellulite at the following link to
Last updated: 8/2/2010