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Duane syndrome type 1


Other Names for this Disease
  • DRS
  • Duane retraction syndrome
  • Duane retraction syndrome 1
  • Duane syndrome
  • DURS
Related Diseases
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Overview

Duane syndrome type 1 is the most common type of Duane syndrome, an eye movement disorder that is present at birth.[1] People with Duane syndrome have restricted ability to move the affected eye(s) outward toward the ear (abduction) and/or inward toward the nose (adduction). The different types are distinguished by the eye movements that are most restricted.[1][2] Duane syndrome type 1 is characterized by absent to very restricted abduction and normal to mildly restricted adduction.[1] The eye opening (palpebral fissure) narrows and the eyeball retracts into the orbit with adduction. With abduction, the reverse occurs.[3] One or both eyes may be affected. The majority of cases are sporadic (not inherited), while about 10% are familial. 70% of affected people do not have any other abnormalities at birth (isolated Duane syndrome).[1]
Last updated: 10/29/2014

References

  1. Caroline V Andrews, David G Hunter, and Elizabeth C Engle. Duane Syndrome. GeneReviews. July 5, 2012; http://www.ncbi.nlm.nih.gov/books/NBK1190/. Accessed 10/29/2014.
  2. Isolated Duane retraction syndrome. Genetics Home Reference. March 2009; http://ghr.nlm.nih.gov/condition/isolated-duane-retraction-syndrome. Accessed 11/18/2011.
  3. Duane Syndrome. NORD. February 2, 2012; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/224/viewAbstract. Accessed 10/29/2014.
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Basic Information

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  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Duane syndrome type 1. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • DRS
  • Duane retraction syndrome
  • Duane retraction syndrome 1
  • Duane syndrome
  • DURS
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.