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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Bilateral frontoparietal polymicrogyria


Other Names for this Disease
  • BFPP
  • Cerebellar ataxia with neuronal migration defect
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Symptoms


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What are the signs and symptoms of bilateral frontoparietal polymicrogyria?

The most commonly reported signs and symptoms in individuals with bilateral frontoparietal polymicrogyria (BFPP) include moderate to severe intellectual disability; motor and cognitive developmental delay; seizures; cerebellar dysfunction; and dysconjugate gaze (eyes that are not aligned). Other findings that have been reported include increased muscle tone; mild truncal ataxia (decreased ability to perform smoothly coordinated voluntary movements); finger dysmetria (difficulty controlling speed, distance and/or power of movements); and strabismus.

In addition to polymicrogyria, brain MRI studies may show enlarged ventricles, reduced white matter volume (showing areas containing nerve fibers), patchy white matter signal changes, and underdevelopment of the cerebellum and brainstem.[1]
Last updated: 8/24/2011

References
  1. Cassandra L. Kniffin. POLYMICROGYRIA, BILATERAL FRONTOPARIETAL. OMIM. March 27, 2006; http://omim.org/entry/606854. Accessed 8/24/2011.