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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Logopenic progressive aphasia


Other Names for this Disease
  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
  • LPA
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Overview



What is logopenic progressive aphasia?

How might logopenic progressive aphasia be treated?

What is the typical life expectancy for people with logopenic progressive aphasia?

What is the prognosis for people with logopenic progressive aphasia?


What is logopenic progressive aphasia?

Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule. Click here to view an image of the lobes of the brain.[1][2]
Last updated: 1/18/2013

How might logopenic progressive aphasia be treated?

No medications have been demonstrated to improve or stabilize logopenic progressive aphasia.[3][4][5] So far cholinesterase inhibitors, the drugs used in Alzheimer’s disease, have not been proven effective in treating logopenic progressive aphasia.[4] Behavioral interventions may be helpful in improving communication difficulties.[6]

The National Aphasia Association provides further information on the medical management of primary progressive aphasias at the following link, which you may find helpful:
http://www.aphasia.org/Aphasia%20Facts/managing_primary_progressive_aphasia.html
Last updated: 1/18/2013

What is the typical life expectancy for people with logopenic progressive aphasia?

Little is known regarding the overall life expectancy of individuals with logopenic progressive aphasia. This dementia is associated with Alzheimer’s disease in the majority of cases.[7] Life expectancy for people with Alzheimer’s disease has been estimated to be between 3 to 10 years.[8] However, due to the many variables that influence life expectancy, making individualized life-expectancy predictions can be very difficult.
Last updated: 1/18/2013

What is the prognosis for people with logopenic progressive aphasia?

Typically during the first few years following disease onset, signs and symptoms primarily involve speech and language problems. Pronounced behavioral problems are not as common in logopenic progressive aphasia, as in other forms of primary progressive aphasia.[9] Caregiver experience of changes in behavioral symptoms and everyday skills has been demonstrated to be similar to that of Alzheimer’s disease.[7]
Last updated: 1/18/2013

References
  1. Ratnavalli E.. Progress in the last decade in our understanding of primary progressive aphasia. Ann Indian Acad Neurol. 2010; 13:S109-S115. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039160/?tool=pubmed. Accessed 2/20/2013.
  2. Primary Progressive Aphasia. UCSF Memory and Aging Center. February 2011; http://memory.ucsf.edu/education/diseases/ppa. Accessed 9/14/2011.
  3. Miller BL Lee SE,. Frontotemporal dementia: Treatment. In: DeKosky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2013;
  4. Amici S, Gorno-Tempini ML, Ogar JM, Dronkers NF, Miller BL. An overview on Primary Progressive Aphasia and its variants. Behav Neurol. 2006;17(2):77-87; http://www.ncbi.nlm.nih.gov/pubmed/16873918. Accessed 1/18/2013.
  5. Randolph C . Frontotermporal dementia: Clinical features and diganosis. In: DeKasky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2012;
  6. Beeson PM, King RM, Bonakdarpour B, Henry ML, Cho H, Rapcsak SZ. Positive effects of language treatment for the logopenic variant of primary progressive aphasia. J Mol Neurosci. 2011 Nov;45(3):724-36; http://www.ncbi.nlm.nih.gov/pubmed/21710364. Accessed 1/18/2013.
  7. Hsieh S, Hodges JR, Leyton CE, Mioshi E. Longitudinal changes in primary progressive aphasias: differences in cognitive and dementia staging measures. Dement Geriatr Cogn Disord. 2012;34(2):135-41; http://www.ncbi.nlm.nih.gov/pubmed/23006977. Accessed 1/18/2013.
  8. Zanetti O, Solerte SB, Cantoni F. Life expectancy in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2009;49 Suppl 1:237-43; http://www.ncbi.nlm.nih.gov/pubmed/19836639. Accessed 1/18/2013.
  9. Le Rhun E, Richard F, Pasquier F. Natural history of primary progressive aphasia. Neurology. 2005 Sep 27;65(6):887-91; http://www.ncbi.nlm.nih.gov/pubmed/16186529. Accessed 1/18/2013.