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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Logopenic progressive aphasia


Other Names for this Disease

  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
  • LPA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might logopenic progressive aphasia be treated?

No medications have been demonstrated to improve or stabilize logopenic progressive aphasia.[1][2][3] So far cholinesterase inhibitors, the drugs used in Alzheimer’s disease, have not been proven effective in treating logopenic progressive aphasia.[2] Behavioral interventions may be helpful in improving communication difficulties.[4]

The National Aphasia Association provides further information on the medical management of primary progressive aphasias at the following link, which you may find helpful:
http://www.aphasia.org/Aphasia%20Facts/managing_primary_progressive_aphasia.html
Last updated: 1/18/2013

References
  1. Miller BL Lee SE,. Frontotemporal dementia: Treatment. In: DeKosky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2013;
  2. Amici S, Gorno-Tempini ML, Ogar JM, Dronkers NF, Miller BL. An overview on Primary Progressive Aphasia and its variants. Behav Neurol. 2006;17(2):77-87; http://www.ncbi.nlm.nih.gov/pubmed/16873918. Accessed 1/18/2013.
  3. Randolph C . Frontotermporal dementia: Clinical features and diganosis. In: DeKasky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2012;
  4. Beeson PM, King RM, Bonakdarpour B, Henry ML, Cho H, Rapcsak SZ. Positive effects of language treatment for the logopenic variant of primary progressive aphasia. J Mol Neurosci. 2011 Nov;45(3):724-36; http://www.ncbi.nlm.nih.gov/pubmed/21710364. Accessed 1/18/2013.
  5. Le Rhun E, Richard F, Pasquier F. Natural history of primary progressive aphasia. Neurology. 2005 Sep 27;65(6):887-91; http://www.ncbi.nlm.nih.gov/pubmed/16186529. Accessed 1/18/2013.
  6. Hsieh S, Hodges JR, Leyton CE, Mioshi E. Longitudinal changes in primary progressive aphasias: differences in cognitive and dementia staging measures. Dement Geriatr Cogn Disord. 2012;34(2):135-41; http://www.ncbi.nlm.nih.gov/pubmed/23006977. Accessed 1/18/2013.
  7. Zanetti O, Solerte SB, Cantoni F. Life expectancy in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2009;49 Suppl 1:237-43; http://www.ncbi.nlm.nih.gov/pubmed/19836639. Accessed 1/18/2013.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Logopenic progressive aphasia. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
  • LPA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.