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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Logopenic progressive aphasia


Other Names for this Disease

  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
  • LPA
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Prognosis

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What is the typical life expectancy for people with logopenic progressive aphasia?

Little is known regarding the overall life expectancy of individuals with logopenic progressive aphasia. This dementia is associated with Alzheimer’s disease in the majority of cases.[1] Life expectancy for people with Alzheimer’s disease has been estimated to be between 3 to 10 years.[2] However, due to the many variables that influence life expectancy, making individualized life-expectancy predictions can be very difficult.
Last updated: 1/18/2013

What is the prognosis for people with logopenic progressive aphasia?

Typically during the first few years following disease onset, signs and symptoms primarily involve speech and language problems. Pronounced behavioral problems are not as common in logopenic progressive aphasia, as in other forms of primary progressive aphasia.[3] Caregiver experience of changes in behavioral symptoms and everyday skills has been demonstrated to be similar to that of Alzheimer’s disease.[1]
Last updated: 1/18/2013

References
  1. Hsieh S, Hodges JR, Leyton CE, Mioshi E. Longitudinal changes in primary progressive aphasias: differences in cognitive and dementia staging measures. Dement Geriatr Cogn Disord. 2012;34(2):135-41; http://www.ncbi.nlm.nih.gov/pubmed/23006977. Accessed 1/18/2013.
  2. Zanetti O, Solerte SB, Cantoni F. Life expectancy in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2009;49 Suppl 1:237-43; http://www.ncbi.nlm.nih.gov/pubmed/19836639. Accessed 1/18/2013.
  3. Le Rhun E, Richard F, Pasquier F. Natural history of primary progressive aphasia. Neurology. 2005 Sep 27;65(6):887-91; http://www.ncbi.nlm.nih.gov/pubmed/16186529. Accessed 1/18/2013.
  4. Miller BL Lee SE,. Frontotemporal dementia: Treatment. In: DeKosky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2013;
  5. Beeson PM, King RM, Bonakdarpour B, Henry ML, Cho H, Rapcsak SZ. Positive effects of language treatment for the logopenic variant of primary progressive aphasia. J Mol Neurosci. 2011 Nov;45(3):724-36; http://www.ncbi.nlm.nih.gov/pubmed/21710364. Accessed 1/18/2013.
  6. Amici S, Gorno-Tempini ML, Ogar JM, Dronkers NF, Miller BL. An overview on Primary Progressive Aphasia and its variants. Behav Neurol. 2006;17(2):77-87; http://www.ncbi.nlm.nih.gov/pubmed/16873918. Accessed 1/18/2013.
  7. Randolph C . Frontotermporal dementia: Clinical features and diganosis. In: DeKasky ST, Eichler AF. UpToDate. Waltham, MA: UpToDate; 2012;


Other Names for this Disease
  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
  • LPA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.