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Genetic and Rare Diseases Information Center (GARD)

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Gray zone lymphoma

Other Names for this Disease
  • Mediastinal gray zone lymphoma
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Your Question

My husband has been diagnosed with gray zone lymphoma.  What are the treatment options for this condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might gray zone lymphoma be treated?

Gray zone lymphoma shares features with two other types of lymphoma, classical Hodgkin lymphoma (cHL) and mediastinal large B-cell lymphoma (MLBCL).  Because MLBCL and cHL are treated differently, it is unclear how gray zone lymphoma should be treated.  At this time, there are no guidelines for the best treatment of gray zone lymphoma; treatment is determined based on each individual's diagnosis.  Treatment usually begins with chemotherapy, which may be followed by radiation therapy in some cases.[1]
Last updated: 5/17/2012

  • Traverse-Glehen A, Pittaluga S, Gaulard P, Sorbara L, Alonso MA, Raffeld M, Jaffe ES. Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. American Journal of Surgical Pathology. 2005; 29:1411-1421. Accessed 5/12/2012.