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Genetic and Rare Diseases Information Center (GARD)

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Acquired pure red cell aplasia

Other Names for this Disease
  • Acquired PRCA
  • Adult pure red cell aplasia
  • Idiopathic pure red cell aplasia
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How might acquired pure red cell aplasia be treated?

The main goals of treatment for pure red cell aplasia (PRCA) are to restore the production of red blood cells, maintain adequate hemoglobin levels, and treat underlying disorders that may be causing the condition. The initial treatment plan typically includes blood transfusions for individuals who are severely anemic and have cardiorespiratory failure.[1] PRCA due to medication or infections is usually reversible within a few months. Therefore, medications that may be causing the condition should be discontinued, and infections that may cause the condition should be treated.[1] Underlying conditions that may cause PRCA such as a thymoma, hematological cancers, solid tumors, and systemic lupus erythematosus (SLE) should be treated as necessary as well.[1] When the condition is idiopathic (of unknown cause) or due to an autoimmune disorder, PRCA is typically initially treated with corticosteroids.[1]

It has been reported that individuals who seem to be resistant to treatment may respond to a single course of intravenous immunoglobulin (IVIG,) while others have responded to a single dose. In the United States, financial issues may make it difficult to obtain this treatment because IVIG is expensive and is not approved by the Food and Drug Administration to treat PRCA.[2]

Additional and more detailed information about the management of acquired PRCA may be found on eMedicine's web site and can be viewed by clicking here.
Last updated: 12/15/2011

  1. Paul Schick. Pure Red Cell Aplasia. eMedicine. October 25, 2011; Accessed 12/14/2011.
  2. Stanley L Schrier. Acquired pure red cell aplasia. UpToDate. Waltham, MA: UpToDate; 2011;
  3. Pure Red Cell Aplasia, Acquired. NORD. August 7, 2007; Accessed 12/14/2011.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Acquired pure red cell aplasia. Click on the link to go to to read descriptions of these studies.