Hereditary diffuse gastric cancer
Other Names for this Disease
- Familial gastric cancer
- Familial stomach cancer
- Gastric cancer, familial diffuse
- Gastric cancer, hereditary diffuse
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Hereditary diffuse gastric cancer is inherited in an autosomal dominant manner. This means that to be affected, a person only needs a change (mutation) in one copy of the responsible gene in each cell. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene. These cases occur in people with no history of the disorder in their family. A person with hereditary diffuse gastric cancer has a 50% chance with each pregnancy of passing along the altered gene to his or her child.
Last updated: 3/17/2015
- Pardeep Kaurah, MSc, CCGC and David G Huntsman, MD. Hereditary Diffuse Gastric Cancer. GeneReviews. July 2014; http://www.ncbi.nlm.nih.gov/books/NBK1139/.