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Genetic and Rare Diseases Information Center (GARD)

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Hereditary diffuse gastric cancer

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Other Names for this Disease
  • Gastric cancer, familial diffuse
  • Gastric cancer, hereditary diffuse
  • HDGC
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Hereditary diffuse gastric cancer is an inherited cancer syndrome that greatly increases the chance of developing cancer of the stomach lining. This syndrome is caused by mutations in the CDH1 gene. In hereditary diffuse gastric cancer, stomach cancer typically develops in a person's late thirties or early forties. Mutations in the CDH1 gene also increase a person's risk for lobular breast cancer. This condition is inherited in an autosomal dominant pattern.[1]
Last updated: 12/16/2011


  1. Kaurah P, Huntsman DG. Hereditary diffuse gastric cancer. GeneReviews. June 2011; Accessed 9/30/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Hereditary diffuse gastric cancer. This website is maintained by the National Library of Medicine.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.