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Hereditary diffuse gastric cancer
Other Names for this Disease
- Gastric cancer, familial diffuse
- Gastric cancer, hereditary diffuse
- HDGC
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Overview
Hereditary diffuse gastric cancer is an inherited cancer syndrome that greatly increases the chance of developing cancer of the stomach lining. This syndrome is caused by mutations in the CDH1 gene. In hereditary diffuse gastric cancer, stomach cancer typically develops in a person's late thirties or early forties. Mutations in the CDH1 gene also increase a person's risk for lobular breast cancer. This condition is inherited in an autosomal dominant pattern.[1]
References
- Kaurah P, Huntsman DG. Hereditary diffuse gastric cancer. GeneReviews. http://www.ncbi.nlm.nih.gov/books/NBK1139/. Accessed September 30, 2011.
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General Information
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Hereditary diffuse gastric cancer. Click on the link to go to OMIM and review these resources.